Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy

Ciumas, C., Robins Wahlin, T. B., Jucaite, A., Lindstrom, P., Halldin, C. and Savic, I. (2008) Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy. Neurology, 71 11: 788-794. doi:10.1212/01.wnl.0000316120.70504.d5


Author Ciumas, C.
Robins Wahlin, T. B.
Jucaite, A.
Lindstrom, P.
Halldin, C.
Savic, I.
Title Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy
Journal name Neurology   Check publisher's open access policy
ISSN 0028-3878
Publication date 2008-09-09
Year available 2008
Sub-type Article (original research)
DOI 10.1212/01.wnl.0000316120.70504.d5
Open Access Status Not yet assessed
Volume 71
Issue 11
Start page 788
End page 794
Total pages 6
Editor R. C. Griggs
Place of publication United States
Publisher Lippincott Wiliams & Wilkins
Language eng
Subject C1
110903 Central Nervous System
110319 Psychiatry (incl. Psychotherapy)
920111 Nervous System and Disorders
920410 Mental Health
Abstract BACKGROUND:: Behavioral and cognitive problems are frequently encountered in juvenile myoclonic epilepsy (JME). The underlying mechanisms are unknown. Based on previous data showing that the dopamine system is involved in motor as well as cognitive functions, we tested whether JME may be associated with changes in this system, and if such changes are linked to interictal dysfunctions in these patients. METHOD:: PET and [C]PE2I was used to investigate the regional binding potential to the dopamine transporter (DAT) in 12 patients with JME and 12 healthy controls. Binding potential was calculated in the midbrain, substantia nigra, caudate, and putamen. We also tested possible correlations between the respective measures and performance in several neuropsychological tests. RESULTS:: Patients had a reduced binding potential in the substantia nigra and midbrain (p ≤ 0.009 and 0.007), and normal values in the caudate and putamen. They also exhibited impaired psychomotor speed and motor function, which in some tests correlated with DAT binding potential in the midbrain. CONCLUSION:: Dopamine signaling seems impaired in the target regions for dopaminergic neurons (the striatum and frontal lobe), and related to several interictal dysfunctions in JME. The findings add a new aspect to the pathophysiology of JME.
Formatted abstract
Background: Behavioral and cognitive problems are frequently encountered in juvenile myoclonic epilepsy (JME). The underlying mechanisms are unknown. Based on previous data showing that the dopamine system is involved in motor as well as cognitive functions, we tested whether JME may be associated with changes in this system, and if such changes are linked to interictal dysfunctions in these patients.

Method: PET and [11C]PE2I was used to investigate the regional binding potential to the dopamine transporter (DAT) in 12 patients with JME and 12 healthy controls. Binding potential was calculated in the midbrain, substantia nigra, caudate, and putamen. We also tested possible correlations between the respective measures and performance in several neuropsychological tests.

Results: Patients had a reduced binding potential in the substantia nigra and midbrain (p = 0.009 and 0.007), and normal values in the caudate and putamen. They also exhibited impaired psychomotor speed and motor function, which in some tests correlated with DAT binding potential in the midbrain.

Conclusion: Dopamine signaling seems impaired in the target regions for dopaminergic neurons (the striatum and frontal lobe), and related to several interictal dysfunctions in JME. The findings add a new aspect to the pathophysiology of JME.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 16 Apr 2009, 01:10:32 EST by Sheila Cleary on behalf of Psychiatry - Royal Brisbane and Women's Hospital