Protease-catalysed protein splicing: a new post-translational modification?

Ivana Saska and Craik, David J. (2008) Protease-catalysed protein splicing: a new post-translational modification?. Trends In Biochemical Sciences, 33 8: 363-368. doi:10.1016/j.tibs.2008.04.016


Author Ivana Saska
Craik, David J.
Title Protease-catalysed protein splicing: a new post-translational modification?
Journal name Trends In Biochemical Sciences   Check publisher's open access policy
ISSN 0968-0004
Publication date 2008-07-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tibs.2008.04.016
Open Access Status
Volume 33
Issue 8
Start page 363
End page 368
Total pages 6
Editor Jonathan Tyzack
Place of publication Cambridge
Publisher Elsevier
Language eng
Subject C1
030406 Proteins and Peptides
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Abstract In all organisms, proteases catalyse peptide-bond hydrolysis and mediate protein function for a multitude of cellular processes. Mechanistically, nothing prevents proteases from also catalysing peptide-bond ligation; however, this 'reverse' reaction rarely is observed. In eukaryotes its presence has been viewed as an anomaly. Recent studies from plants and animals now challenge this assumption, indicating that protease-catalysed protein splicing is a bona fide post-translational modification. Increasing evidence indicates that the proximity of protein substrates, imposed either by their structure or by the physical constraints of the local environment, dictates when the splicing reaction will occur. This previously under-recognized splicing mechanism could increase intracellular protein diversity, thereby expanding the size of the proteome and sequence diversity beyond the predictions from genomic studies.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
BIOCHEMISTRY & MOLECULAR BIOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 16 Apr 2009, 00:28:29 EST by Jennifer Greder on behalf of Institute for Molecular Bioscience