Phonemic fluency deficits in asymptomatic gene carriers for Huntington's disease

Larsson, Maria U., Almkvist, Ove, Luszcz, Mary A. and Robins Wahlin, Tarja-Brita (2008) Phonemic fluency deficits in asymptomatic gene carriers for Huntington's disease. Neuropsychology, 22 5: 596-605. doi:10.1037/0894-4105.22.5.596

Author Larsson, Maria U.
Almkvist, Ove
Luszcz, Mary A.
Robins Wahlin, Tarja-Brita
Title Phonemic fluency deficits in asymptomatic gene carriers for Huntington's disease
Journal name Neuropsychology   Check publisher's open access policy
ISSN 0894-4105
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1037/0894-4105.22.5.596
Open Access Status
Volume 22
Issue 5
Start page 596
End page 605
Total pages 10
Editor S. M. Rao
Place of publication United States
Publisher American Psychological Association
Language eng
Subject C1
110319 Psychiatry (incl. Psychotherapy)
170205 Neurocognitive Patterns and Neural Networks
920111 Nervous System and Disorders
920410 Mental Health
Formatted abstract
The aim of the present study was to investigate verbal fluency in preclinical Huntington’s disease (HD).  Phonemic and semantic fluency and the rate of word production over time were assessed for 29 asymptomatic gene carriers and 34 noncarriers of HD. The relationship between fluency tasks and other cognitive domains was investigated. Compared to noncarriers, carriers produced fewer words and produced them more slowly in the phonemic fluency task but not in the semantic fluency task. When the carrier group was divided on the basis of Predicted-Years-To-Onset (PYTO), only carriers with <12 PYTO performed worse than noncarriers on both fluency tasks. Correlational analyses revealed that phonemic fluency was associated with cognitive speed and working memory, while semantic fluency was linked with crystallized abilities. The difference between carriers and noncarriers in phonemic fluency and a difference between the two carrier groups (<12 PYTO and >12 PYTO) in semantic fluency, but not in phonemic fluency, suggest that frontostriatal deficits may precede temporal involvement in preclinical HD.
Keyword Huntington's disease
verbal fluency
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 16 Apr 2009, 00:12:54 EST by Sheila Cleary on behalf of Psychiatry - Royal Brisbane and Women's Hospital