Comparison of different nutritional assessments and body-composition measurements in detecting malnutrition among gynecologic cancer patients

Laky, Brenda, Janda, Monika, Cleghorn, Geoffrey J. and Obermair, Andreas (2008) Comparison of different nutritional assessments and body-composition measurements in detecting malnutrition among gynecologic cancer patients. American Journal of Clinical Nutrition, 87 6: 1678-1685.


Author Laky, Brenda
Janda, Monika
Cleghorn, Geoffrey J.
Obermair, Andreas
Title Comparison of different nutritional assessments and body-composition measurements in detecting malnutrition among gynecologic cancer patients
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 87
Issue 6
Start page 1678
End page 1685
Total pages 9
Place of publication Bethesda, M.D, U.S.A.
Publisher American Society for Nutrition
Language eng
Subject C1
111299 Oncology and Carcinogenesis not elsewhere classified
920102 Cancer and Related Disorders
Abstract Background: Few studies have assessed global nutritional assessment tools and body-composition measurements in gynecologic cancer patients. Objective: We aimed to assess the convergent validity of different nutritional tools such as the scored Patient-Generated Subjective Global Assessment (PG-SGA), serum albumin, skinfold-thickness measurements, and total-body potassium (TBK) and body density measurements to identify gynecologic cancer patients at risk of malnutrition. Design: We assessed the nutritional status of 194 patients with suspected or proven gynecologic cancer according to the SGA and the scored PG-SGA, and skinfold-thickness (n = 145), TBK (n = 51), and body density measurements (n = 42) before primary treatment. Results: According to the SGA and the scored PG-SGA global rating, 24% of gynecologic cancer patients were classified as malnourished. The prevalence of malnutrition was highest in ovarian (67%) and lowest in endometrial (6%) cancer patients. The ability of the PG-SGA score (P < 0.001) and albumin (P < 0.001), triceps skinfold-thickness (P = 0.041), and TBK (P = 0.005) measurements to predict the SGA was significantly better than chance. TBK significantly correlated with measurements associated with protein depletion, including age (P < 0.001), arm muscle area (P < 0.001), fat-free mass (P < 0.001), and the PG-SGA score (P = 0.009). Multiple regression analysis showed that, together, the PG-SGA score and arm muscle area adjusted for age accounted for 66% of total TBK variance. Conclusions: The PG-SGA is significantly associated with subjective and objective parameters and is a widely recognized, clinically relevant method of evaluating nutritional status. It therefore seems most appropriate for identifying malnourishment in gynecologic cancer patients.
Keyword Subjective Global Assessment
Arm muscle area
Ovarian-cancer
Serum-albumin
Weight-loss
Cytoreductive Surgery
Skeletal-muscle
Energy-balance
Screening Tools
Older-people
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Apr 2009, 22:11:21 EST by Helen Spindler on behalf of School of Medicine