Biological response of chickens (Gallus gallus domesticus) induced to corticosterone and a bacterial endotoxin.

Shini, Shaniko, Kaiser, Pete, Shini, Agim and Bryden, Wayne L. (2008) Biological response of chickens (Gallus gallus domesticus) induced to corticosterone and a bacterial endotoxin.. Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology, 149 2: 324-333. doi:10.1016/j.cbpb.2007.10.003


Author Shini, Shaniko
Kaiser, Pete
Shini, Agim
Bryden, Wayne L.
Title Biological response of chickens (Gallus gallus domesticus) induced to corticosterone and a bacterial endotoxin.
Journal name Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology   Check publisher's open access policy
ISSN 1096-4959
1879-1107
Publication date 2008-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.cbpb.2007.10.003
Open Access Status Not yet assessed
Volume 149
Issue 2
Start page 324
End page 333
Total pages 10
Editor Patrick J. Walsh
Thomas P. Mommsen
Place of publication New York
Publisher Elsevier Science
Language eng
Subject C1
070702 Veterinary Anatomy and Physiology
830309 Poultry
Abstract Experiments were conducted with chickens exposed to corticosterone and lipopolysaccharide (LPS) from Escherichia coli, with the aim of evaluating and differentiating their effects on endocrine, metabolic and immune response. Both, corticosterone and LPS significantly elevated plasma corticosterone concentrations and increased heterophil to lymphocyte (H/L) ratios 1 h, 3 h and 24 h post-treatments. Repeated exposure to corticosterone caused a prolonged elevation of plasma corticosterone concentration and H/L ratio. Data on blood metabolites demonstrated that corticosterone stimulated hyperglycaemia, hypercholesterolemia and hypertriglyceridemia. In contrast, LPS induced hypocholesterolemia and hypotriglyceridemia at 24 h post-injection. Weight gain and relative weight of the spleen and bursa were reduced in chickens treated with corticosterone. The LPS did not show any significant effect on weekly weight gain, but stimulated an increase in the relative weight of the spleen. Corticosterone initially stimulated antibody responsiveness to infectious bronchitis virus (IBV) vaccination, but thereafter the titres decreased. This was in contrast to LPS which depressed the antibody titre to IBV vaccination. It was concluded that the biological response of chickens induced by corticosterone could be differed from the response to LPS. The major difference occurred in metabolic, growth and immune activities. It appears that, both corticosterone and LPS differently alter physiological, metabolic and immunological responses of chickens through an activation of different molecular components (cytokines and chemokines) and neuroendocrine-immune network systems.
Keyword Corticosterone
Lipopolysaccharide (LPS)
Chickens; Stress
Plasma metabolites
Immune response
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Epublication 16 October 2007, then in print Feb 2008. Should have been claimed in 08HERDC

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Agriculture and Food Sciences
 
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Created: Wed, 15 Apr 2009, 01:58:03 EST by Mrs Kathy Bachmann on behalf of School of Animal Studies