Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model

Wang, Xue-Qing, Kempf, Margit, Liu, Pei-Yun, Cuttle, Leila, Chang, Hong-En, Kravchuk, Olena, Mill, Julie, Phillips, Gael E and Kimble, Roy M. (2008) Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model. Wound Repair and Regeneration, 16 6: 774-783. doi:10.1111/j.1524-475X.2008.00428.x


Author Wang, Xue-Qing
Kempf, Margit
Liu, Pei-Yun
Cuttle, Leila
Chang, Hong-En
Kravchuk, Olena
Mill, Julie
Phillips, Gael E
Kimble, Roy M.
Title Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model
Journal name Wound Repair and Regeneration   Check publisher's open access policy
ISSN 1067-1927
1524-475X
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1524-475X.2008.00428.x
Open Access Status
Volume 16
Issue 6
Start page 774
End page 783
Total pages 10
Editor Patricia Hebda
Place of publication Malden, M. A.
Publisher Blackwell Science
Language eng
Subject 321000 Clinical Sciences
321013 Neurology and Neuromuscular Diseases
C1
920118 Surgical Methods and Procedures
Abstract In thermal deep-dermal burns, surgical debridement is normally used in conjunction with skin grafting or skin substitutes and debridement alone as a burn treatment is not usually practiced. The current study addresses whether or not debridement alone would enhance burn wound healing on small deep-dermal-partial thickness burns. This was a prospective and blinded experimental trial using a porcine deep-dermal-partial thickness burn model. Four burns, approximately 50 cm(2) in size, were created on each of eight pigs. Two burns from each pig were immediately surgically debrided and the other two were not debrided as the internal control. Hydrate gel together with paraffin gauze were used to cover the burns for four pigs and silver dressings for the other four. Clinical assessment of wound healing was conducted over a 6-week period. Skin samples were collected at the end of the experiment and histopathological evaluation was performed. The results show thinner scar formation and lower scar height in the debrided compared with nondebrided wounds in the hydrate gel/paraffin gauze groups. There were no statistically significant differences in wound healing assessment between the debrided and nondebrided wounds dressed with silver dressings. This study provides supporting evidence that immediate debridement with an appropriate dressing and without skin grafting may promote wound healing, suggesting its potential benefit for clinical patients.
Keyword burns
wound healing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Apr 2009, 01:40:44 EST