Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers

Doecke, J D, Zhao, Z Z, Stark, M S, Green, A C, Hayward, N K, Montgomery, G W, Webb, P M and Whiteman, D C (2008) Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiology, Biomarkers & Prevention, 17 4: 1007-1012. doi:10.1158/1055-9965.EPI-08-0023

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Author Doecke, J D
Zhao, Z Z
Stark, M S
Green, A C
Hayward, N K
Montgomery, G W
Webb, P M
Whiteman, D C
Title Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers
Journal name Cancer Epidemiology, Biomarkers & Prevention   Check publisher's open access policy
ISSN 1055-9965
Publication date 2008-01-01
Year available 2008
Sub-type Editorial
DOI 10.1158/1055-9965.EPI-08-0023
Open Access Status
Volume 17
Issue 4
Start page 1007
End page 1012
Total pages 6
Place of publication United States
Publisher American Association for Cancer Reseacrh
Language eng
Subject C1
111201 Cancer Cell Biology
111203 Cancer Genetics
Abstract Rates of adenocarcinoma of the esophagus (EAC) and esophagogastric junction (EGJAC) have been rising rapidly in recent decades, in contrast to the declining rates of esophageal squamous cell carcinomas (ESCC)d. Obesity is a major risk factor for both EAC and EGJAC, but not ESCC, and there is speculation that obesity promotes adenocarcinoma development through endocrine and related pathways. We therefore compared the prevalence of 12 single nucleotide polymorphisms (SNPs) in nine candidate genes previously implicated in obesity pathways (LEP, LEPR, ADIPOQ, POMC, PPAR alpha, PPAR-gamma, RXR-gamma, GHRL, and INSIG2) in a large Australian case-control study comprising DNA samples from 260 EAC cases, 301 EGJAC cases, 213 ESCC cases, and 1,352 population controls. No SNPs were associated with EGJAC or ESCC. Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ Us1501299), LEP (5'-untranslated region), PPAR gamma (1-14471-1), and GHRL (M72L)](r) effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. Further, we found no consistent evidence that any of the genotypes were associated with risk of EAC or EGJAC within strata of body mass index (<25.0 kg/m(2), 25.0-29.9 kg/m(2), >30 kg/m(2)). In conclusion, our data suggest that these SNPs do not play a major role in esophageal carcinogenesis.
Keyword single nucleotide polymorphisms
obesity-related genes
esophageal cancers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Editorial
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Apr 2009, 00:09:23 EST by Amy Wong on behalf of Medicine - Royal Brisbane and Women's Hospital