Dysfunction in the fronto-parietal network in attention deficit hyperactivity disorder (ADHD: An fMRI Study

Silk, Timothy J., Vance, Alasdair, Rinehart, Nicole, Bradshaw, John L. and Cunnington, Ross (2008) Dysfunction in the fronto-parietal network in attention deficit hyperactivity disorder (ADHD: An fMRI Study. Brain Imaging and Behavior, 2 2: 123-131. doi:10.1007/s11682-008-9021-8


Author Silk, Timothy J.
Vance, Alasdair
Rinehart, Nicole
Bradshaw, John L.
Cunnington, Ross
Title Dysfunction in the fronto-parietal network in attention deficit hyperactivity disorder (ADHD: An fMRI Study
Journal name Brain Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7557
1931-7565
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s11682-008-9021-8
Open Access Status DOI
Volume 2
Issue 2
Start page 123
End page 131
Total pages 9
Editor Andrew J. Saykin
Place of publication New York, U.S.A.
Publisher Springer
Language eng
Subject C1
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
970117 Expanding Knowledge in Psychology and Cognitive Sciences
1109 Neurosciences
Abstract ADHD is associated with spatial working memory deficits, thought to be subserved by dysfunction of neural circuits. In this study we aimed to further examine fronto-parietal dysfunction in ADHD by examining brain activation associated with the Raven’s Progressive Matrices task, a visuo-spatial pattern sequencing task involving relational reasoning and thereby placing high-demand loading on the prefrontal cortex. Functional MRI was conducted on twelve right-handed 8–12 year old boys with ADHD-combined type and 12 right-handed, age and performance IQ-matched, healthy boys as they completed items from the Raven’s Progressive Matrices. Our findings further confirm striatum and parietal lobe dysfunction in ADHD. Furthermore, dysfunction in lateral prefrontal regions was found. In addition to lateral prefrontal, striatum and posterior parietal regions, the temporal lobe was also less active. These findings suggest deficits in a widespread ‘functional network’ in ADHD that may be fundamental for visuo-spatial information processing and relational reasoning.
Keyword ADHD
Striatum
Parietal lobe
Functional magnetic resonance imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 384419
Institutional Status UQ

 
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Created: Tue, 14 Apr 2009, 21:41:13 EST by Debra McMurtrie on behalf of Queensland Brain Institute