The internal control group in a register of antiepileptic drug use in pregnancy

Vajda, F J E, O'Brien, T, Hitchcock, A, Graham, J, Lander, C and Eadie, M (2008) The internal control group in a register of antiepileptic drug use in pregnancy. Journal of Clinical Neuroscience, 15 1: 29-35. doi:10.1016/j.jocn.2006.10.015

Author Vajda, F J E
O'Brien, T
Hitchcock, A
Graham, J
Lander, C
Eadie, M
Title The internal control group in a register of antiepileptic drug use in pregnancy
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1016/j.jocn.2006.10.015
Open Access Status
Volume 15
Issue 1
Start page 29
End page 35
Total pages 7
Editor Kaye, A H
Place of publication United Kingdom
Publisher Churchill Livingston
Language eng
Subject C1
110502 Dental Therapeutics, Pharmacology and Toxicology
Abstract The aim of this study was to determine how valid 68 first-trimester pregnancies of untreated epileptic women would prove as an internal control group for investigating foetal malformation rates in 709 simultaneously collected antiepileptic drug-exposed pregnancies in an Australian register of pregnancies in epileptic women. We carried out comparisons of values for parameters relating to personal details, obstetric aspects, and epilepsies prior to and during pregnancy in the drug-exposed and drug-unexposed pregnancies, with observations on subpopulations within the drug-unexposed group. Statistically significant (p < 0.05) differences existed for only seven of more than 50 parameters compared. None of these seven parameters had a statistically significant influence on foetal malformation rates in the whole dataset. In 23 of the 65 epileptic pregnancies unexposed to antiepileptic drugs, therapy had been ceased shortly prior to pregnancy and was often resumed after the first trimester. In the remaining 42, therapy had been ceased earlier, often despite continuing seizures. Planned withdrawal of therapy did not appear to produce additional hazards for mothers and foetuses in the former subgroup. In the data collection studied, there did not appear to be evidence of statistically significant differences between untreated pregnancies and treated epileptic pregnancies that would be likely to invalidate the former group as an internal control for the latter, at least when assessing foetal malformation rates.
Keyword Epilepsy
Antiepileptic Drugs
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Tue, 14 Apr 2009, 19:41:41 EST by Amy Wong on behalf of Medicine - Royal Brisbane and Women's Hospital