An arthritogenic alphavirus uses the α1β1 integrin collagen receptor

Linn, May La, Eble, Johannes A., Lübken, Christoph, Slade, Robert, W., Heino, Jyrki, Davies, Janet M. and Suhrbier, Andreas (2005) An arthritogenic alphavirus uses the α1β1 integrin collagen receptor. Virology, 336 2: 229-239. doi:10.1016/j.virol.2005.03.015

Author Linn, May La
Eble, Johannes A.
Lübken, Christoph
Slade, Robert, W.
Heino, Jyrki
Davies, Janet M.
Suhrbier, Andreas
Title An arthritogenic alphavirus uses the α1β1 integrin collagen receptor
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
Publication date 2005-06-05
Sub-type Article (original research)
DOI 10.1016/j.virol.2005.03.015
Open Access Status DOI
Volume 336
Issue 2
Start page 229
End page 239
Total pages 11
Place of publication San Diego, U.S.A.
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1107 Immunology
Abstract Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding α1β1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the β1 and α1 integrin proteins, and fibroblasts from α1-integrin−/− mice were less efficiently infected than wild-type fibroblasts. Soluble α1β1 integrin bound immobilized RR virus, and peptides representing the α1β1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions within the cell-receptor binding domain of E2 mimic collagen and provide access to cellular collagen-binding receptors.
Keyword Ross River virus
α1β1 integrin
Collagen IV
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Fri, 10 Apr 2009, 02:19:00 EST by Ms Julie Schofield on behalf of Faculty Of Health Sciences