Self-assembly of amphiphilic polymeric dendrimers synthesized with selective degradable linkages

Urbani, Carl N., Bell, Craig A., Lonsdale, Daria, Whittaker, Michael R. and Monteiro, Michael J. (2008) Self-assembly of amphiphilic polymeric dendrimers synthesized with selective degradable linkages. Macromolecules, 41 1: 76-86. doi:10.1021/ma701993w

Author Urbani, Carl N.
Bell, Craig A.
Lonsdale, Daria
Whittaker, Michael R.
Monteiro, Michael J.
Title Self-assembly of amphiphilic polymeric dendrimers synthesized with selective degradable linkages
Journal name Macromolecules   Check publisher's open access policy
ISSN 0024-9297
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1021/ma701993w
Open Access Status
Volume 41
Issue 1
Start page 76
End page 86
Total pages 11
Editor Timothy P. Lodge
Place of publication Washington, D. C.
Publisher ACS Publications
Language eng
Subject C1
030306 Synthesis of Materials
870303 Polymeric Materials (e.g. Paints)
Abstract Enhancing the structural complexity and functionality of building blocks allows the design and synthesis of complex macromolecular architectures. In this work, we use a combination of atom transfer radical polymerization to produce polymers with well-defined chain length and telechelic end group functionality and “click” reactions to quantitatively couple these polymer chains together to form functional second- and third-generation dendrimers. Importantly, this methodology provides starting polymers in combination with linkers and end group protecting chemistries to design dendrimers with degradable linkages between the desired generations and incorporates functionality at the polymer chain ends of each generation. We have synthesized second- and third-generation homo- and amphiphilic diblock copolymer dendrimers and specifically designed third-generation dendrimers in pure form such that the peripheral generational layer could be selectively cleaved off from the second-generation. The degradation of the peripheral polymer layer is a useful feature in biomedical delivery devices for slow and controlled release of its payload. These dendrimers also have either “free” or protected hydroxyl groups on the peripheral ends, which are useful for further chemical modification or chemical coupling to important biomolecules. The amphiphilic dendrimers self-assemble in water to form well-defined micelles of near identical size (18.2 nm, PDI = 1.04), each consisting of approximately 19 individual dendrimers. The dense core of the spherical micelles found from sizing measurements supports the postulate that these amphiphilic dendrimers have no mutual interpenetration and thus pack uniformly to form the micelles.
Keyword Living Radical Polymerization
Terminator Multifunctional Initiator
Dendritic Macromolecules
Divergent Synthesis
Iterative Strategy
Star Polymers
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes First published online 12/12/07 then in hard copy Jan 2008. Should have been claimed in 2008 Collection. Cannot claim under 'Publication year' for 09HERDC

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 72 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 76 times in Scopus Article | Citations
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Created: Thu, 09 Apr 2009, 20:15:47 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology