Divergent synthesis and self-assembly of amphiphilic polymeric dendrons with selective degradable linkages

Urbani, Carl N., Lonsdale, Daria E., Bell, Craig A., Whittaker, Michael R. and Monteiro, Michael J. (2008) Divergent synthesis and self-assembly of amphiphilic polymeric dendrons with selective degradable linkages. Journal of Polymer Science: Part A Polymer Chemistry, 46 5: 1533-1547. doi:10.1002/pola.22528


Author Urbani, Carl N.
Lonsdale, Daria E.
Bell, Craig A.
Whittaker, Michael R.
Monteiro, Michael J.
Title Divergent synthesis and self-assembly of amphiphilic polymeric dendrons with selective degradable linkages
Journal name Journal of Polymer Science: Part A Polymer Chemistry   Check publisher's open access policy
ISSN 0887-624X
Publication date 2008-03-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/pola.22528
Open Access Status Not yet assessed
Volume 46
Issue 5
Start page 1533
End page 1547
Total pages 15
Editor Mitsuo Samamoto
Virgil Percec
Craig J. Hawker
Karen L. Wooley
E. W. Meijer
Place of publication USA
Publisher Wiley
Language eng
Subject C1
030306 Synthesis of Materials
870303 Polymeric Materials (e.g. Paints)
Abstract Enhancing the structural complexity and functionality of the building blocks allows the construction of supramolecular assemblies. In this work, we demonstrate a strategy for the design and synthesis of complex macromolecular architectures. We use atom transfer radical polymerization to produce well-defined polymers with telechelic end-group functionality, and click them together to form functional 3rd generation dendrons, and incorporated degradable linkages and certain functionality at the polymer chain-ends of each generation. The 3rd generation polymeric dendrons consisted of homopolymer polystyrene (PSTY) with either four solketals or eight alcohols, diblock PSTY and poly(t-butyl acrylate), and amphiphilic diblock. The peripheral ends consisting of alcohols create functionalization points for further chemical modification or chemical coupling and the cleavable linkages between the 2nd and 3rd generations all provide the first steps toward smart nanostructures. Importantly, we can synthesize these dendrons in pure form. The self-assembly of the amphiphilic dendrons (the inner and outer generations consisting of PSTY and polyacrylic acid, respectively) in water produced micelles of uniform size with an aggregation number of 43 dendrons per micelle. The size of the micelles was small (DH =20.7 nm) and comparable to the size found by transmission electron microscopy (14-18 nm). © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 1533-1547, 2008
Keyword block copolymers
hyperbranched
functionalization of polymers
living radical polymerization
self-assembly
supramolecular structures
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Thu, 09 Apr 2009, 19:47:48 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology