Outcome of antibiotic therapy for third-generation cephalosporin-resistant Gram-negative bacteraemia: an analysis of 249 cases caused by Citrobacter, Enterobacter and Serratia species

Kim, Baek-Nam, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Nam Joong, Woo, Jun-Hee, Ryu, Jiso and Kim, Yang Soo (2003) Outcome of antibiotic therapy for third-generation cephalosporin-resistant Gram-negative bacteraemia: an analysis of 249 cases caused by Citrobacter, Enterobacter and Serratia species. International journal of antimicrobial agents, 22 2: 106-111. doi:10.1016/S0924-8579(03)00094-3


Author Kim, Baek-Nam
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Nam Joong
Woo, Jun-Hee
Ryu, Jiso
Kim, Yang Soo
Title Outcome of antibiotic therapy for third-generation cephalosporin-resistant Gram-negative bacteraemia: an analysis of 249 cases caused by Citrobacter, Enterobacter and Serratia species
Journal name International journal of antimicrobial agents   Check publisher's open access policy
ISSN 0924-8579
1872-7913
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1016/S0924-8579(03)00094-3
Open Access Status
Volume 22
Issue 2
Start page 106
End page 111
Total pages 6
Place of publication Amsterdam
Publisher Elsevier Science
Language eng
Subject 110309 Infectious Diseases
111205 Chemotherapy
Abstract Two hundred and forty-nine patients with monomicrobial bacteraemia due to third-generation cephalosporin (TGC)-resistant Citrobacter freundii (42), E. aerogenes (23), E. cloacae (143), and Serratia marcescens (41) were analyzed for antibiotic therapy used and outcome. For isolates with resistance to any of the TGCs, all β-lactams, except imipenem, were considered ineffective. Of 152 patients given appropriate treatment, the mortality rates were 10.9% for 128 patients given monotherapy and 25.0% for 24 patients given combination therapy (P=0.09). Of patients given monotherapy, there were no significant differences in mortality between imipenem, aminoglycoside, and ciprofloxacin treatment groups (P=0.57). Only shock was associated with mortality in multivariate analysis. In conclusion, for patients with TGC-resistant Gram-negative bacteraemia, no significant difference in outcome was observed between single antibiotic therapy groups or monotherapy and combination therapy groups.
Keyword Cephalosporins
Resistance
Citrobacter
Enterobacter
Serratia
Bacteraemia
Treatment outcome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 09 Apr 2009, 19:46:06 EST by Ms Sarada Rao on behalf of Anaesthesiology and Critical Care - RBWH