Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis

Greer, Judith M. and Pender, Michael P. (2008). Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis. In: A. Richard Kitching, Mechanisms of Autoimmunity: A Tribute to Professor Ian Mackay - A selection of papers presented at the 11th Australasian Autoimmunity Workshop. 11th Australasian Autoimmunity Workshop, Melbourne, VIC, Australia, (281-287). 6 - 8 July 2007. doi:10.1016/j.jaut.2008.04.018


Author Greer, Judith M.
Pender, Michael P.
Title of paper Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis
Conference name 11th Australasian Autoimmunity Workshop
Conference location Melbourne, VIC, Australia
Conference dates 6 - 8 July 2007
Proceedings title Mechanisms of Autoimmunity: A Tribute to Professor Ian Mackay - A selection of papers presented at the 11th Australasian Autoimmunity Workshop   Check publisher's open access policy
Journal name Journal of Autoimmunity   Check publisher's open access policy
Place of Publication London, United Kingdom
Publisher Academic Press
Publication Year 2008
Year available 2008
Sub-type Fully published paper
DOI 10.1016/j.jaut.2008.04.018
Open Access Status
ISSN 0896-8411
1095-9157
Editor A. Richard Kitching
Volume 31
Issue 3
Start page 281
End page 287
Total pages 7
Language eng
Abstract/Summary Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.
Subjects C1
920111 Nervous System and Disorders
920108 Immune System and Allergy
110703 Autoimmunity
110903 Central Nervous System
Keyword Antibody
Autoimmunity
Central nervous system
Demyelination
Inflammation
Multiple sclerosis
Myelin proeolipid protein
Post-translational modification
T cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 09 Apr 2009, 10:07:50 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research