Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers

Dalley, A.J., Lipman, J., Deans, R., Venkatesh, B., Rudd, M., Roberts, M.S. and Cross, S.E. (2009) Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers. Antimicrobial Agents and Chemotherapy, 53 1: 210-215. doi:10.1128/AAC.00718-08

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Author Dalley, A.J.
Lipman, J.
Deans, R.
Venkatesh, B.
Rudd, M.
Roberts, M.S.
Cross, S.E.
Title Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 2009-10-27
Year available 2008
Sub-type Article (original research)
DOI 10.1128/AAC.00718-08
Open Access Status File (Publisher version)
Volume 53
Issue 1
Start page 210
End page 215
Total pages 6
Editor G.M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject C1
920118 Surgical Methods and Procedures
110303 Clinical Microbiology
110310 Intensive Care
Abstract Burn tissue sites are a potential source of bacteremia during debridement surgery. Burn injury is likely to affect the distribution of antibiotics to tissues, but direct evidence of this is lacking. The aim of this study was to directly evaluate the influence of burn trauma on the distribution of cephalothin to peripheral tissues. We used subcutaneous microdialysis techniques to monitor interstitial fluid concentrations of cephalothin in the burnt and nonburnt tissues of adult patients with severe burns following parenteral administration of 1 g cephalothin for surgical prophylaxis. Analogous simultaneous studies conducted with healthy adult volunteers provided reference tissue concentration data. Equivalent tissue exposures were seen for burn and nonburn sites, giving overall median interstitial cephalothin concentrations (from 0 to 240 min) of 2.84 mg/liter and 3.06 mg/liter, respectively. A lower overall median interstitial cephalothin concentration of 0.54 mg/liter was observed for healthy individuals, and the patient nonburnt tissue and volunteer control tissue cephalothin concentrations exhibited significantly different data distributions (P < 0.001; Kolmogorov-Smirnov nonparametric test). The duration of tissue residence for cephalothin was longer for burn patients than for healthy volunteers. The results demonstrate the potential fallibility of using healthy population models to extrapolate tissue pharmacodynamic predictions from plasma data for burn patients.
Keyword Microbiology
Pharmacology & Pharmacy
Microbiology
Pharmacology & Pharmacy
MICROBIOLOGY
PHARMACOLOGY & PHARMACY
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 351519
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 09 Apr 2009, 01:32:08 EST by Denise Wilson on behalf of School of Medicine