Mucins in the mucosal barrier to infection

Linden, S. K., Sutton, P., Karlsson, N.G., Korolik, V. and McGuckin, M. A. (2008) Mucins in the mucosal barrier to infection. Mucosal Immunology, 1 3: 183-197. doi:10.1038/mi.2008.5

Author Linden, S. K.
Sutton, P.
Karlsson, N.G.
Korolik, V.
McGuckin, M. A.
Title Mucins in the mucosal barrier to infection
Journal name Mucosal Immunology   Check publisher's open access policy
ISSN 1933-0219
Publication date 2008-05-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/mi.2008.5
Volume 1
Issue 3
Start page 183
End page 197
Total pages 15
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110801 Medical Bacteriology
Abstract The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that cause human disease. Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia. In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive immunity and mucins, and the strategies used by successful mucosal pathogens to subvert or avoid the mucin barrier, with a particular focus on bacteria.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 348 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 377 times in Scopus Article | Citations
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Created: Thu, 09 Apr 2009, 01:19:51 EST by Joanne PRESTON on behalf of Faculty Of Health Sciences