Soluble CD38 significantly prolongs the lifespan of memory B-cell responses

Liu, X.Q., Hart, D.N.J., MacPherson, G.G., Good, M.F. and Wykes, M.N. (2008) Soluble CD38 significantly prolongs the lifespan of memory B-cell responses. Immunology, 125 1: 14-20. doi:10.1111/j.1365-2567.2008.02914.x


Author Liu, X.Q.
Hart, D.N.J.
MacPherson, G.G.
Good, M.F.
Wykes, M.N.
Title Soluble CD38 significantly prolongs the lifespan of memory B-cell responses
Journal name Immunology   Check publisher's open access policy
ISSN 0019-2805
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-2567.2008.02914.x
Open Access Status Not Open Access
Volume 125
Issue 1
Start page 14
End page 20
Total pages 7
Place of publication United States of America
Publisher Wiley-Blackwell Publishing Ltd
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110704 Cellular Immunology
Abstract The development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen-specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.
Keyword B Cells
CD83
Follicular Dendritic Cells
immunological Memory
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 09 Apr 2009, 00:03:01 EST by Joanne PRESTON on behalf of School of Medicine