Desmoplastic melanoma: the role of radiotherapy in improving local control

Foote, M. C., Burmeister, B., Burmeister, E., Bayley, G. and Smithers, B. M. (2008) Desmoplastic melanoma: the role of radiotherapy in improving local control. Australian and New Zealand Journal of Surgery, 78 4: 273-276. doi:10.1111/j.1445-2197.2008.04436.x


Author Foote, M. C.
Burmeister, B.
Burmeister, E.
Bayley, G.
Smithers, B. M.
Title Desmoplastic melanoma: the role of radiotherapy in improving local control
Journal name Australian and New Zealand Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1445-2197.2008.04436.x
Open Access Status Not yet assessed
Volume 78
Issue 4
Start page 273
End page 276
Total pages 4
Editor Gough, I
Chapuis, P. H.
Hall, J. C.
Place of publication Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111208 Radiation Therapy
11 Medical and Health Sciences
1112 Oncology and Carcinogenesis
Abstract Background: Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of local disease. We conducted a retrospective analysis of patients with DM treated through the Princess Alexandra Hospital Melanoma Clinic to address the role of radiotherapy in the local control of this tumour.
Formatted abstract
 Background:  Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of local disease. We conducted a retrospective analysis of patients with DM treated through the Princess Alexandra Hospital Melanoma Clinic to address the role of radiotherapy in the local control of this tumour.

Methods:  A review of a clinical database identified 24 patients between January 1997 and March 2006 with histopathologically confirmed DM who had received surgical excision as initial treatment followed by postoperative radiotherapy. All histopathology reports and radiotherapy treatment plans were reviewed. The primary outcome measure was 3-year in-field relapse-free survival.

Results:  There were 24 patients with 22 having a DM in the head and neck region. The median tumour thickness was 5.2 mm. The histopathological margin was less than 10 mm in 17 (71%) of patients. The 3-year in-field relapse-free survival was 91% (95% confidence interval 68.1–97.6%), the 3-year relapse-free survival was 86% (95% confidence interval 63.2–95.4%) with a 3-year overall survival of 83% (95% confidence interval 54.9–94.3%).

Conclusion:  In a selected series of patients with DM with a high risk of local recurrence, adjuvant radiotherapy may have been effective in reducing the rate of local recurrence after surgical resection. A randomized trial is currently being developed to confirm this possible benefit.

Keyword Desmoplastic melanoma
Local control
Neurotropic melanoma
Radiotherapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 08 Apr 2009, 23:27:02 EST by Maree Knight on behalf of Faculty Of Health Sciences