Renal pathology, glomerular number and volume in a West African urban community

McNamara, Bridgette J., Diouf, Boucar, Hughson, Michael D., Douglas-Denton, Rebecca N., Hoy, Wendy E. and Bertram, John F. (2008) Renal pathology, glomerular number and volume in a West African urban community. Nephrology, Dialysis, Transplantation, 23 8: 2576-2585. doi:10.1093/ndt/gfn039


Author McNamara, Bridgette J.
Diouf, Boucar
Hughson, Michael D.
Douglas-Denton, Rebecca N.
Hoy, Wendy E.
Bertram, John F.
Title Renal pathology, glomerular number and volume in a West African urban community
Journal name Nephrology, Dialysis, Transplantation   Check publisher's open access policy
ISSN 0931-0509
1460-2385
Publication date 2008-08-01
Year available 2008
Sub-type Article (original research)
DOI 10.1093/ndt/gfn039
Open Access Status Not yet assessed
Volume 23
Issue 8
Start page 2576
End page 2585
Total pages 10
Place of publication Oxford, U.K.
Publisher Oxford University Press
Language eng
Subject C1
110312 Nephrology and Urology
110316 Pathology (excl. Oral Pathology)
1103 Clinical Sciences
Abstract Background. Low glomerular number and large glomerular volume are hypothesized to be risk factors for hypertensive renal disease in adult life. Reports of human glomerular number are based on studies from developed nations and have found single kidney mean values of similar to 900 000 per kidney with a roughly 8-fold range matched by a similar range in glomerular volume. Glomerular number and volume have never been investigated in people from a developing country.
Formatted abstract
Background 
Low glomerular number and large glomerular volume are hypothesized to be risk factors for hypertensive renal disease in adult life. Reports of human glomerular number are based on studies from developed nations and have found single kidney mean values of ~900 000 per kidney with a roughly 8-fold range matched by a similar range in glomerular volume. Glomerular number and volume have never been investigated in people from a developing country.

Methods
This study analysed the pathology of 81 autopsy kidneys from Dakar, Senegal, and determined total glomerular number and mean glomerular volume in 28 of these kidneys using the physical disector/fractionator method.

Results
Total glomerular number ranged 2.6-fold from 536 171 to 1 394 010, with a mean of 925 485 nephrons. The mean glomerular volume was 5.74 µm3 x 106 with a 2.5-fold variation that was strongly and inversely correlated with total glomerular number. Glomerular number was inversely correlated with age, and age-associated increases in arteriosclerosis, cortical fibrosis and glomerulosclerosis were observed. Arteriolar nephrosclerosis was observed in 34% of adults. Mean glomerular number in this Dakar population was similar to that previously reported for people from developed nations, while the range of glomerular number and mean glomerular volume was much narrower.

Conclusions
The frequency of arteriolar nephrosclerosis in these Senegalese adults was high (34%), suggesting that hypertensive kidney disease could contribute to a large burden of future chronic kidney disease in this population. Unusually low glomerular number or large glomerular volume do not appear to provide a basis for this potential burden of kidney disease.
© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Keyword Arteriosclerosis
Glomerular volume
Nephron number
Renal pathology
Senegal
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 DK065970
5P20M00534-02
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 08 Apr 2009, 22:14:57 EST by Amy Wong on behalf of Medicine - Royal Brisbane and Women's Hospital