Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials

Brooke, Gary, Rossetti, Tony, Pelekanos, Rebecca, Ilic, Nina, Murray, Patricia, Hancock, Sonia, Antonenas, Vicki, Huang, Gillian, Gottlieb, David, Bradstock, Ken and Atkinson, Kerry (2009) Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials. British Journal of Haematology, 144 4: 571-579. doi:10.1111/j.1365-2141.2008.07492.x

Author Brooke, Gary
Rossetti, Tony
Pelekanos, Rebecca
Ilic, Nina
Murray, Patricia
Hancock, Sonia
Antonenas, Vicki
Huang, Gillian
Gottlieb, David
Bradstock, Ken
Atkinson, Kerry
Title Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials
Journal name British Journal of Haematology   Check publisher's open access policy
ISSN 1365-2141
ISBN 1-85317-660-5
Publication date 2009-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1365-2141.2008.07492.x
Open Access Status Not yet assessed
Volume 144
Issue 4
Start page 571
End page 579
Total pages 9
Place of publication Oxford, England
Publisher Blackwell Publishing Ltd
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110708 Transplantation Immunology
Abstract Mesenchymal stem cells (MSC) are being used increasingly in clinical trials for a range of regenerative and inflammatory diseases. Bone marrow is the traditional source but is relatively inaccessible in large volume. MSC have now been derived from tissues other than bone marrow including placenta and adipose tissue. We have used placenta obtained after delivery as a source of MSC and have been unable to detect any marked differences from marrow-derived MSC in terms of cell surface phenotype, chemokine receptor display, mesodermal differentiation capacity or immunosuppressive ability. This report described our manufacturing process for isolating and expanding placenta-derived human MSC and their safe infusion into the first patient in a clinical trial program of human placenta-derived MSC.
Keyword Mesenchymal Stem Cells
Cell Therapy
Good Manufacturing Practice Production
Clinical Trial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 104 times in Scopus Article | Citations
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Created: Wed, 08 Apr 2009, 21:57:32 EST by Joanne PRESTON on behalf of Medicine - Mater Hospital