Cutaneous adverse drug reactions induced by systemic antihistamines are very rarely observed [1–3] ; these are usually generalized and explosive, appearing as urticaria, erythema multiforme or anaphylactic shock [4, 5] .
In the present study, we report a case of a woman who developed a generalized eczematous reaction in the course of systemic therapy with cetirizine and levocetirizine.
Histologic features were characteristic enough to give a relevant diagnostic aid.