Effects of subthalamic deep brain stimulation on noun/verb generation and selection from competing alternatives in Parkinson's disease

Castner, J. E., Chenery, H. J., Silburn, P. A., Coyne, T. J., Sinclair, F., Smith, E. R. and Copland, D. A. (2008) Effects of subthalamic deep brain stimulation on noun/verb generation and selection from competing alternatives in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 79 6: 700-705. doi:10.1136/jnnp.2007.118729


Author Castner, J. E.
Chenery, H. J.
Silburn, P. A.
Coyne, T. J.
Sinclair, F.
Smith, E. R.
Copland, D. A.
Title Effects of subthalamic deep brain stimulation on noun/verb generation and selection from competing alternatives in Parkinson's disease
Journal name Journal of Neurology, Neurosurgery, and Psychiatry   Check publisher's open access policy
ISSN 0022-3050
1468-330X
1473-7086
1474-7758
Publication date 2008-06-01
Year available 2007
Sub-type Article (original research)
DOI 10.1136/jnnp.2007.118729
Open Access Status DOI
Volume 79
Issue 6
Start page 700
End page 705
Total pages 6
Editor M. Rosser
Place of publication London, United Kingdom
Publisher BMJ Group
Language eng
Subject C1
920107 Hearing, Vision, Speech and Their Disorders
110321 Rehabilitation and Therapy (excl. Physiotherapy)
Abstract Background and aim: Impaired generation of verbs relative to nouns has been reported in Parkinson's disease (PD) and has been associated with the frontal pathophysiology of PD. The aim of the present study was to measure noun/verb generation abilities in PD and to determine whether noun/verb generation is affected by stimulation of the subthalamic nucleus (STN).
Formatted abstract
Background and aim:
Impaired generation of verbs relative to nouns has been reported in Parkinson’s disease (PD) and has been associated with the frontal pathophysiology of PD. The aim of the present study was to measure noun/verb generation abilities in PD and to determine whether noun/verb generation is affected by stimulation of the subthalamic nucleus (STN).

Patients and methods:
8 participants who had been diagnosed with PD and had received surgery for deep brain stimulation (DBS) of the STN as well as 15 control participants completed a noun/verb generation task with four probe–response conditions—namely, noun–noun, verb–noun, noun–verb and verb–verb conditions. Patients with PD were assessed while receiving STN stimulation and without stimulation.

Results
:
During the off stimulation condition, patients with PD presented with a selective deficit in verb generation compared with control participants. However, when receiving STN stimulation, patients with PD produced significantly more errors than controls during the noun–noun and verb–verb conditions, supporting evidence from previous studies that STN stimulation modulates a frontotemporal network associated with word generation. Finally, errors during verb generation were significantly correlated with item selection constraint (ie, the degree to which a response competes with other response alternatives) in the on stimulation condition, but not the off stimulation condition.

Conclusion
:
Our results suggest that STN stimulation affects the ability to select from many competing lexical alternatives during verb generation.
Keyword Chronic bilateral stimulation
Verbal fluency
Basal ganglia
Follow-up
Nucleus
Retrieval
Cortex
Nouns
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published Online First: 2 October 2007, then in print June 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 08 Apr 2009, 03:09:12 EST by Meredith Downes on behalf of School of Health & Rehabilitation Sciences