Subthalamic stimulation affects homophone meaning generation in Parkinson's disease

Castner, J. E., Copland, D. A., Silburn, P. A., Coyne, T., Sinclair, F. and Chenery, H. J. (2008) Subthalamic stimulation affects homophone meaning generation in Parkinson's disease. Journal of the International Neuropsychological Society, 14 5: 890-894. doi:10.1017/S1355617708081046

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Author Castner, J. E.
Copland, D. A.
Silburn, P. A.
Coyne, T.
Sinclair, F.
Chenery, H. J.
Title Subthalamic stimulation affects homophone meaning generation in Parkinson's disease
Journal name Journal of the International Neuropsychological Society   Check publisher's open access policy
ISSN 1355-6177
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1017/S1355617708081046
Open Access Status File (Publisher version)
Volume 14
Issue 5
Start page 890
End page 894
Total pages 5
Editor Haaland, K.
Place of publication United Kingdom
Publisher Cambridge University Press
Language eng
Subject C1
920107 Hearing, Vision, Speech and Their Disorders
110321 Rehabilitation and Therapy (excl. Physiotherapy)
Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in individuals with Parkinson's disease (PD) has often been associated with reduced verbal fluency performance. This study aimed to directly assess semantic switching as a function of STN stimulation in PD participants with the Homophone Meaning Generation Test (HMGT). Seventeen participants with PD who had received STN DBS completed the HMGT in on and off stimulation conditions. Twenty-one non-neurologically impaired participants acted as controls. PD participants (in both on and off stimulation conditions) generated significantly fewer meanings than control participants and consistent with the previous reports of verbal fluency impairment, PD participants produced fewer definitions in the on stimulation condition. PD participants (in both on and off stimulation conditions) also had greater difficulty generating definitions for nonhomographic homophones compared with homographic homographs. The results of this study indicate that STN stimulation exacerbates impairment in semantic switching.
Keyword Clinical Neurology
Neurosciences & Neurology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Health and Rehabilitation Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 08 Apr 2009, 02:48:28 EST by Meredith Downes on behalf of School of Health & Rehabilitation Sciences