Convergent synthesis of second generation AB-Type miktoarm dendrimers using "Click" chemistry catalyzed by copper wire

Urbani, Carl N., Bell, Craig A., Whittaker, Michael R. and Monteiro, Michael J. (2008) Convergent synthesis of second generation AB-Type miktoarm dendrimers using "Click" chemistry catalyzed by copper wire. Macromolecules, 41 4: 1057-1060. doi:10.1021/ma702707e


Author Urbani, Carl N.
Bell, Craig A.
Whittaker, Michael R.
Monteiro, Michael J.
Title Convergent synthesis of second generation AB-Type miktoarm dendrimers using "Click" chemistry catalyzed by copper wire
Journal name Macromolecules   Check publisher's open access policy
ISSN 0024-9297
Publication date 2008-01-31
Year available 2008
Sub-type Article (original research)
DOI 10.1021/ma702707e
Open Access Status DOI
Volume 41
Issue 4
Start page 1057
End page 1060
Total pages 4
Editor Timothy P. Lodge
Place of publication Washington, D.C.
Publisher American Chemical Society
Language eng
Subject C1
030306 Synthesis of Materials
870303 Polymeric Materials (e.g. Paints)
Abstract Dendrimers synthesized from small molecules form macromolecules of well-defined size and architecture.1 The high density of functional groups on the periphery of the dendrimers makes them useful as carriers for multiple copies of biologically active compounds for drug/vaccine delivery or probe molecules for detection applications.2 However, the typical synthetic procedure for obtaining dendrimers from small molecules limits their size to about 5−15 nm as each new generation is increasingly difficult to add and contributes only to a relatively small increase in dimensions. In addition, traditional dendrimers are difficult to purify and as a consequence costly. Thus, the focus in synthetic dendrimers has shifted from using small molecule to polymeric building blocks made by living radical polymerization.3 However, there is still a need in precise synthetic tools that would allow one to combine polymeric blocks with diverse functionality into one structure to create advanced products for biomedical and coatings applications.
Keyword Polymer Science
Polymer Science
POLYMER SCIENCE
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 07 Apr 2009, 23:01:38 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology