Mobilization of hematopoietic stem cells: state of the art

Levesque, J-P. J. R. and Winkler, I.G. (2008) Mobilization of hematopoietic stem cells: state of the art. Current Opinion in Organ Transplantation, 13 1: 53-58. doi:10.1097/MOT.0b013e3282f42473


Author Levesque, J-P. J. R.
Winkler, I.G.
Title Mobilization of hematopoietic stem cells: state of the art
Journal name Current Opinion in Organ Transplantation   Check publisher's open access policy
ISSN 1087-2418
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MOT.0b013e3282f42473
Open Access Status DOI
Volume 13
Issue 1
Start page 53
End page 58
Total pages 6
Place of publication United States of America
Publisher Lippencott, Williams & Wilkins
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
060103 Cell Development, Proliferation and Death
Abstract Purpose of review: Hematopoietic stem cells (HSCs) normally reside in the bone marrow but can be forced into the blood, a process termed mobilization used clinically to harvest large numbers of HSCs for transplantation. Currently the mobilizing agent of choice is granulocyte colony-stimulating factor; however, not all patients mobilize well. This article reviews recent advances in understanding the molecular mechanisms responsible for the retention of HSCs in the bone marrow, which are perturbed during HSC mobilization, and the clinical application of these findings. Recent findings: The interaction between the chemokine SDF-1/CXCL12 and its receptor CXCR4 is critical to retain HSCs within the bone marrow, leading to the discovery that small synthetic CXCR4 antagonists are potent mobilizing agents that synergize with granulocyte colony-stimulating factor. Separate research has shown that HSC numbers in the bone marrow can be boosted by increasing the number of osteoblasts that support HSCs. Summary: HSC mobilization induced by granulocyte colony-stimulating factor may be enhanced by directly targeting the chemotactic interaction between HSCs and bone marrow stroma with CXCR4 antagonists. When the primary problem is reduced, however, HSC numbers in the bone marrow, due to repeated chemotherapy/radiotherapy treatments, an alternative is to enhance HSC content by enhancing bone formation prior to mobilization.
Keyword Cxcr4 Antagonist
granulocyte colony stimulating factor
hematopoietic stem cell
Mobilization
parathyroid hormone
Transplantation
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID P50 CA094056
R21 CA110489
R50 CA211466
R21 CA132269
UL1 RR024992
R01 CA152329
R01 CA083845
P30 CA091842
P01 CA101937
UL1 TR000448
R21 CA141523
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 07 Apr 2009, 21:48:54 EST by Joanne PRESTON on behalf of School of Medicine