A novel switch region regulated H-ras membrane orientation and signal output

Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J., Gorfe, Alemayehu A, Parton, Robert G., McCammon, J. Andrew and Hancock, John F. (2008) A novel switch region regulated H-ras membrane orientation and signal output. The EMBO journal, 27 5: 727-735. doi:10.1038/emboj.2008.10


Author Abankwa, Daniel
Hanzal-Bayer, Michael
Ariotti, Nicolas
Plowman, Sarah J.
Gorfe, Alemayehu A
Parton, Robert G.
McCammon, J. Andrew
Hancock, John F.
Title A novel switch region regulated H-ras membrane orientation and signal output
Journal name The EMBO journal   Check publisher's open access policy
ISSN 0261-4189
1460-2075
Publication date 2008-02-14
Year available 2008
Sub-type Article (original research)
DOI 10.1038/emboj.2008.10
Open Access Status Not yet assessed
Volume 27
Issue 5
Start page 727
End page 735
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject C1
270104 Membrane Biology
730108 Cancer and related disorders
Abstract The plasma membrane nanoscale distribution of H-ras is regulated by guanine nucleotide binding. To explore the structural basis of H-ras membrane organization, we combined molecular dynamic simulations and medium-throughput FRET measurements on live cells.
Keyword FRET
microdomain
nanocluster
plasma membrane
Ras
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 GM066717
Institutional Status UQ

 
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