Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway

Chung, Wendy Y., Gardiner, Donald L., Hyland, Catharine and Trenholme, Katharine R. (2008) Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway. Parasitology Research, 102 2: 259-263. doi:10.1007/s00436-007-0756-8


Author Chung, Wendy Y.
Gardiner, Donald L.
Hyland, Catharine
Trenholme, Katharine R.
Title Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway
Formatted title
Invasion of Rh null cells by Plasmodium falciparum identifies a new invasion pathway
Journal name Parasitology Research   Check publisher's open access policy
ISSN 0932-0113
Publication date 2008-12-03
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00436-007-0756-8
Open Access Status Not yet assessed
Volume 102
Issue 2
Start page 259
End page 263
Total pages 15
Editor B. Chobotar
H. Mehlhorn
Place of publication Germany
Publisher Springer
Language eng
Subject C1
92 Health
111799 Public Health and Health Services not elsewhere classified
Formatted abstract
The malaria parasite, Plasmodium falciparum, invades the human erythrocyte through a complex interaction with erythrocyte receptors characterized by patterns of resistance to various enzymes. As invasion rates are influenced by blood group polymorphisms, we reasoned that the extremely rare rhesus null (Rhnull) erythrocytes could be informative in characterizing receptors. The aim was to test whether the complete absence of the Rh complex from the cell membrane impacted on parasite invasion. Enzyme treatment patterns for four P. falciparum isolates were first characterised for normal Rh cells. Two isolates showed an enzyme treatment pattern not hitherto described, with resistance to neuraminidase, trypsin and chymotrypsin. In contrast, all isolates had enhanced invasion rates for the Rhnull cell for all enzyme treatment regimens. The first finding suggests there is another pathway that P. falciparum can utilise to invade the host. We speculate that the Rh null cell membrane exposes a novel ligand defined as Receptor N.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Public Health Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 07 Apr 2009, 02:12:57 EST by Amanda Jones on behalf of Faculty Of Health Sciences