The hematopoietic stem cell niche: what are we trying to replicate?

Michael Hines, Nielsen, Lars K. and Cooper-White, Justin J. (2008) The hematopoietic stem cell niche: what are we trying to replicate?. Journal of Chemical Technology and Biotechnology, 83 4: 421-443. doi:10.1002/jctb.1856

Author Michael Hines
Nielsen, Lars K.
Cooper-White, Justin J.
Title The hematopoietic stem cell niche: what are we trying to replicate?
Journal name Journal of Chemical Technology and Biotechnology   Check publisher's open access policy
ISSN 0268-2575
Publication date 2008-02-18
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jctb.1856
Open Access Status Not yet assessed
Volume 83
Issue 4
Start page 421
End page 443
Total pages 23
Editor J. Melling
Place of publication Chichester, U.K.
Publisher Wiley
Language eng
Subject C1
100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
860899 Human Pharmaceutical Products not elsewhere classified
Abstract The pluripotent nature and self-renewal capability of hematopoietic stem cells (HSCs) has resulted in these cells being seen as the ideal cell source for the on-demand production of blood and blood products. This potential to save many thousands of lives is as yet unmet, owing to our inability to reliably expand this cell source ex vivo to clinically relevant numbers. This is, to a large extent, due to the absence of a single cell surface antigen to identify them and an optimum set of in vitro conditions sufficient to expand them while maintaining stemness. This review briefly summarizes the current research efforts aimed at defining the appropriate in vivo conditions to be mimicked in ex vivo culture. In particular, it focuses on the molecules known to participate in the functionality of the bone marrow stem cell niche. These niche molecules include adhesion molecules, extracellular matrix molecules, and soluble and bound growth factors. Finally, this review proposes an approach to find the optimum conditions for this expansion utilizing smart surfaces and a criterion for developing these surfaces. Copyright © 2008 Society of Chemical Industry
Keyword Biotechnology & Applied Microbiology
Chemistry, Multidisciplinary
Engineering, Environmental
Engineering, Chemical
Biotechnology & Applied Microbiology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
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Created: Tue, 07 Apr 2009, 01:45:40 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology