Biopolymer microparticle and nanoparticle formation within a microfluidic device

Rondeau, Elisabeth and Cooper-White, Justin J. (2008) Biopolymer microparticle and nanoparticle formation within a microfluidic device. Langmuir, 24 13: 6937-6945. doi:10.1021/la703339u


Author Rondeau, Elisabeth
Cooper-White, Justin J.
Title Biopolymer microparticle and nanoparticle formation within a microfluidic device
Journal name Langmuir   Check publisher's open access policy
ISSN 0743-7463
Publication date 2008-07-01
Year available 2008
Sub-type Article (original research)
DOI 10.1021/la703339u
Open Access Status Not yet assessed
Volume 24
Issue 13
Start page 6937
End page 6945
Total pages 9
Editor D. G. Whitten
J. F. Holzwarth
R. G. Nuzzo
R. Crooks
Place of publication Washington D.C. USA
Publisher American Chemical Society
Language eng
Subject C1
100708 Nanomaterials
090499 Chemical Engineering not elsewhere classified
970110 Expanding Knowledge in Technology
Abstract This paper reports a novel microfluidic method for the production of cross-linked alginate microparticles and nanoparticles. We describe a continuous process relying on both thermodynamic and hydrodynamic factors to form microdroplets. A rapid cross-linking reaction thereafter allows solidification of the polymer droplets either within the microfluidic device or “off-chip” to form alginate micro- and nanoparticles. Monodisperse droplets are generated by extruding an aqueous alginate solution using an axisymmetric flow-focusing design. As they flow downstream in the channel, due to water and the continuous phase being partially miscible, the water diffuses very slowly out of the polymeric droplets into the transport fluid, which causes the shrinkage of the drops and the condensation of the polymer phase. The resulting size of the solid particles depends on the polymer concentration and the ensuing balance between the kinetics of the cross-linking reaction and the volume loss due to solvent diffusion. This work details both a single-step microfluidic technique for the formation of alginate microparticles of sizes ranging from 1 to 50 μm via near-equilibrium solvent diffusion within a microfluidic device and thereafter a two-step method, which was shown to generate biopolymer nanoparticles of sizes ranging from 10 to 300 nm. These novel methodologies are extremely flexible and can be extended to the preparation of micro- and nanoparticles from a wide range of single or mixed synthetic and biologically derived polymers.
Keyword CA-ALGINATE MICROSPHERES
SOL-GEL TRANSITION
SODIUM ALGINATE
SOLVENT EXTRACTION/EVAPORATION
ANTISENSE OLIGONUCLEOTIDES
POLYMER PARTICLES
CALCIUM-IONS
GELATION
BEADS
MICROCAPSULES
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication Date (Web): May 30, 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 07 Apr 2009, 01:16:26 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology