Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review

Baxi, S.H., Burmeister, B., Harvey, J., Smithers, B.M. and Thomas, J. (2009) Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review. Journal of Medical Imaging and Radiation Oncology, 52 6: 583-587. doi:10.1111/j.1440-1673.2008.02023.x


Author Baxi, S.H.
Burmeister, B.
Harvey, J.
Smithers, B.M.
Thomas, J.
Title Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1440-1673.2008.02023.x
Open Access Status Not yet assessed
Volume 52
Issue 6
Start page 583
End page 587
Total pages 5
Editor Ball, D.
Place of publication Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject C1
920102 Cancer and Related Disorders
110320 Radiology and Organ Imaging
11 Medical and Health Sciences
1112 Oncology and Carcinogenesis
Abstract To determine the overall survival and gastrointestinal toxicity for patients treated with salvage definitive chemo-radiotherapy after primary surgery for locoregional relapse of oesophageal carcinoma. A retrospective review of 525 patients who had a resection for oesophageal or oesophagogastric carcinoma at Princess Alexandra Hospital identified 14 patients treated with salvage definitive radiotherapy or chemo-radiotherapy, following localized recurrence of their disease. We analysed the patient and treatment characteristics to determine the median overall survival as the primary end point. Gastrointestinal toxicity was examined to determine if increased toxicity occurred when the stomach was irradiated within the intrathoracic radiotherapy field. The median overall survival for patients treated with curative intent using salvage definitive chemo-radiotherapy was 16 months and the 2-year overall survival is 21%. One patient is in clinical remission more than 5 years after therapy. Age <60 years old and nodal recurrence were favourable prognostic factors. Treatment compliance was 93% with only one patient unable to complete the intended schedule. Fourteen per cent of patients experienced grade 3 or 4 gastrointestinal toxicity. Salvage definitive chemo-radiotherapy should be considered for good performance status patients with oesophageal carcinoma who have a locoregional relapse after primary surgery. The schedule is tolerable with low toxicity and an acceptable median survival.
Keyword Recurrent oesophageal carcinoma
Salvage chemo-radiotherapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Mon, 06 Apr 2009, 22:38:44 EST by Denise Wilson on behalf of Medicine - Princess Alexandra Hospital