Sox8 is a critical regulator of adult Sertoli cell function and male fertility

O'Bryan, Moira K., Takada, Shuji, Kennedy, Claire L., Scott, Greg, Harada, Shun-ichi, Ray, Manas K., Dai, Qunsheng., Wilhelm, Dagmar, de Krester, David M., Eddy, E. Mitch, Koopman, Peter and Mishina, Yuji (2008) Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Developmental Biology, 316 2: 359-370. doi:10.1016/j.ydbio.2008.01.042


Author O'Bryan, Moira K.
Takada, Shuji
Kennedy, Claire L.
Scott, Greg
Harada, Shun-ichi
Ray, Manas K.
Dai, Qunsheng.
Wilhelm, Dagmar
de Krester, David M.
Eddy, E. Mitch
Koopman, Peter
Mishina, Yuji
Title Sox8 is a critical regulator of adult Sertoli cell function and male fertility
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
1095-564X
Publication date 2008-04-15
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2008.01.042
Open Access Status Not yet assessed
Volume 316
Issue 2
Start page 359
End page 370
Total pages 11
Place of publication San Diego, California, USA
Publisher Elsevier
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
1103 Clinical Sciences
Abstract Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form group E of the Sox gene family which has been implicated in several human developmental disorders. In contrast to other SoxE genes, the role of Sox8 is unclear and Sox8 mouse mutants reportedly showed only idiopathic weight loss and reduced bone density. The careful analysis of our Sox8 null mice, however, revealed a progressive male infertility phenotype. Sox8 null males only sporadically produced litters of reduced size at young ages. We have shown that SOX8 protein is a product of adult Sertoli cells and its elimination results in an age-dependent deregulation of spermatogenesis, characterized by sloughing of spermatocytes and round spermatids, spermiation failure and a progressive disorganization of the spermatogenic cycle, which resulted in the inappropriate placement and juxtaposition of germ cell types within the epithelium. Those sperm that did enter the epididymides displayed abnormal motility. These data show that SOX8 is a critical regulator of adult Sertoli cell function and is required for both its cytoarchitectural and paracrine interactions with germ cells.
Keyword Testis
Fertility
Sox
Sperm
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID Z01 ES070076-21
Z01 ES071003
Institutional Status UQ

 
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Created: Mon, 06 Apr 2009, 21:29:37 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience