Lipid droplet-organelle interactions; sharing the fats

Murphy, Samantha, Martin, Sally and Parton, Robert G. (2009) Lipid droplet-organelle interactions; sharing the fats. BBA - Molecular and Cell Biology of Lipids, 1791 6: 441-447. doi:10.1016/j.bbalip.2008.07.004

Author Murphy, Samantha
Martin, Sally
Parton, Robert G.
Title Lipid droplet-organelle interactions; sharing the fats
Journal name BBA - Molecular and Cell Biology of Lipids   Check publisher's open access policy
ISSN 1388-1981
Publication date 2009-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.bbalip.2008.07.004
Open Access Status Not yet assessed
Volume 1791
Issue 6
Start page 441
End page 447
Total pages 7
Place of publication Amsterdam, Netherland
Publisher Elsevier Science
Language eng
Subject C1
060106 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
970106 Expanding Knowledge in the Biological Sciences
Abstract Lipid droplets (LDs) are key cellular organelles involved in lipid storage and mobilisation. While the major signalling cascades and many of the regulators of lipolysis have been identified, the cellular interactions involved in lipid mobilisation and release remain largely undefined. In non-adipocytes, LDs are small, mobile and interact with other cellular compartments. In contrast, adipocytes primarily contain very large, immotile LDs. The striking morphological differences between LDs in adipocytes and non-adipocytes suggest that key differences must exist in the manner in which LDs in different cell types interact with other organelles. Recent studies have highlighted the complexity of LD interactions, which can be both homotypic, with each other, and heterotypic, with other organelles. The molecules involved in these interactions are also now emerging, including Rab proteins, key regulators of membrane traffic, and caveolin, an integral membrane protein providing a functional link between the cell surface and LDs. Here we summarise recent insights into the cell biology of the LD particularly focussing on the homotypic and heterotypic interactions in both adipocytes and non-adipocytes. We speculate that these interactions may involve inter-organelle membrane contact sites or a hemi-fusion type mechanism to facilitate lipid transfer.
Keyword Motility
Lipid Droplet
organelle interaction
rab GTPase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 30 July 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 156 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 06 Apr 2009, 20:52:18 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience