Longitudinal changes in [latin capital V with dot above]O2max: associations with carotid IMT and arterial stiffness

Ferreira, Isabel, Twisk, Jos, Stehouwer , Coen, van Mechelen, Willem and Kemper, Han (2003) Longitudinal changes in [latin capital V with dot above]O2max: associations with carotid IMT and arterial stiffness. Medicine and science in sports and exercise, 35 10: 1670-1678. doi:10.1249/01.MSS.0000089247.37563.4B


Author Ferreira, Isabel
Twisk, Jos
Stehouwer , Coen
van Mechelen, Willem
Kemper, Han
Title Longitudinal changes in [latin capital V with dot above]O2max: associations with carotid IMT and arterial stiffness
Journal name Medicine and science in sports and exercise   Check publisher's open access policy
ISSN 0195-9131
Publication date 2003-10-01
Year available 2003
Sub-type Article (original research)
DOI 10.1249/01.MSS.0000089247.37563.4B
Open Access Status
Volume 35
Issue 10
Start page 1670
End page 1678
Total pages 9
Place of publication Maryland, MO, U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject 1106 Human Movement and Sports Science
Formatted abstract
 Purpose:
High levels of cardiorespiratory fitness ([latin capital V with dot above]O2max) are associated with reduced risk of cardiovascular morbidity and mortality. However, little is known to what extent longitudinal changes in [latin capital V with dot above]O2max affect arterial wall thickness and stiffness, i.e., two major risk factors for cardiovascular disease. We therefore investigated the relationship between changes in [latin capital V with dot above]O2max from adolescence (13-16 yr) to adulthood (age 36) and from young adulthood (21-32 yr) to age 36, and carotid intima-media thickness (IMT) and stiffness of the carotid, femoral, and brachial arteries, at age 36.

Methods:

Analyses of changes in [latin capital V with dot above]O2max from adolescence to age 36 consisted of 154 subjects (79 women), and from young adulthood to age 36 consisted of a subpopulation of 118 subjects (62 women). Throughout the years, [latin capital V with dot above]O2max was measured directly with a maximal running test on a treadmill. When the subjects had the mean age of 36, carotid IMT and large artery stiffness (distensibility and compliance coefficients) were assessed noninvasively by ultrasound imaging methods.

Results:

Longitudinal changes in [latin capital V with dot above]O2max were not significantly associated with carotid IMT. Changes in [latin capital V with dot above]O2max were inversely and significantly associated with large artery stiffness. These associations were not uniform throughout the arterial tree, being stronger and independent of changes in other risk factors in the muscular (brachial and femoral) arteries but dependent on and possibly mediated by concomitant changes in HDL cholesterol and body weight in the elastic carotid artery.

Conclusion:

Increases in [latin capital V with dot above]O2max that occur from adolescence up to age 36 are associated with less arterial stiffness. Improving [latin capital V with dot above]O2max by increasing physical activity levels may therefore contribute to a reduction in mortality from cardiovascular disease through decreasing arterial stiffness.
Keyword Sport Sciences
Sport Sciences
SPORT SCIENCES
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Mon, 06 Apr 2009, 18:18:30 EST by Ms Lynette Adams on behalf of School of Human Movement and Nutrition Sciences