Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus

Simerska, Pavla, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2008) Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus. Biopolymers - Peptide Science, 90 5: 611-616. doi:10.1002/bip.20992

Author Simerska, Pavla
Abdel-Aal, Abu-Baker M.
Fujita, Yoshio
Batzloff, Michael R.
Good, Michael F.
Toth, Istvan
Title Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus
Journal name Biopolymers - Peptide Science   Check publisher's open access policy
ISSN 0006-3525
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/bip.20992
Open Access Status
Volume 90
Issue 5
Start page 611
End page 616
Total pages 6
Editor Heather Benson
Istvan Toth
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject C1
030499 Medicinal and Biomolecular Chemistry not elsewhere classified
920109 Infectious Diseases
Abstract Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14.
Keyword vaccine
group A streptococcus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Variant titles 1. Biopolymers. Peptide science -- 2. Biopolymers. Nucleic acid sciences -- 3. Biopolymers. Biospectroscopy. -- Published Online: 31 Mar 2008. This article was originally published online as an accepted preprint. The Published Online date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at -- Editors for this article are Heather Benson, Istvan Toth.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 03 Apr 2009, 23:32:29 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences