Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis

Catts, V. S., Catts, S. V., O'Toole, B. I. and Frost, A. D. J. (2008) Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis. Acta Psychiatrica Sancdinavica, 117 5: 323-336. doi:10.1111/j.1600-0447.2008.01163.x


Author Catts, V. S.
Catts, S. V.
O'Toole, B. I.
Frost, A. D. J.
Title Cancer incidence in patients with schizophrenia and their first-degree relatives - a meta-analysis
Journal name Acta Psychiatrica Sancdinavica   Check publisher's open access policy
ISSN 0001-690X
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-0447.2008.01163.x
Open Access Status DOI
Volume 117
Issue 5
Start page 323
End page 336
Total pages 14
Editor Munk-Jorgensen, P.
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Language eng
Subject C1
110319 Psychiatry (incl. Psychotherapy)
111202 Cancer Diagnosis
920410 Mental Health
920102 Cancer and Related Disorders
Abstract Objective: Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings.
Formatted abstract
Objective:  Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings.
Method:  A meta-analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first-degree relatives and compared with general population samples.
Results: The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95–1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01–1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84–0.94) and parents (SIR = 0.90, CI 0.88–0.93) was significantly reduced. A metaregression detected a significant relationship between cancer risk in the general population and relative risk in patients.
Conclusion: The meta-analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect.
Keyword schizophrenia
neoplasms
apoptosis
epidemiology
meta-analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 03 Apr 2009, 22:28:33 EST by Sheila Cleary on behalf of Psychiatry - Royal Brisbane and Women's Hospital