Birthweight and arterial stiffness and blood pressure in adulthood - Results from the Amsterdam Growth and Health Longitudinal Study

Te Velde, Saskia J., Ferreira, Isabel, Twisk, Jos W. R., Stehouwer, Coen D. A., Van Mechelen, Willem and Kemper, Han C. G. (2004) Birthweight and arterial stiffness and blood pressure in adulthood - Results from the Amsterdam Growth and Health Longitudinal Study. International Journal of Epidemiology, 33 1: 154-161. doi:10.1093/ije/dyh011


Author Te Velde, Saskia J.
Ferreira, Isabel
Twisk, Jos W. R.
Stehouwer, Coen D. A.
Van Mechelen, Willem
Kemper, Han C. G.
Title Birthweight and arterial stiffness and blood pressure in adulthood - Results from the Amsterdam Growth and Health Longitudinal Study
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 0300-5771
1464-3685
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1093/ije/dyh011
Open Access Status
Volume 33
Issue 1
Start page 154
End page 161
Total pages 8
Place of publication Oxford
Publisher Oxford University Press
Language eng
Subject 1117 Public Health and Health Services
Abstract Background: The association between low birthweight and increased blood pressure in later life has repeatedly been confirmed. Increased arterial stiffness may be an underlying mechanism for this phenomenon. This study investigated whether birthweight was related to blood pressure and local and regional arterial stiffness. Methods: In 281 subjects (161 women), with a mean age of 36, blood pressure was measured. The diameter, distension, and local pulse pressure of three large arteries were measured simultaneously using ultrasound imaging. Local and regional arterial compliance and distensibility were calculated. Information on birthweight was retrieved with a questionnaire. Results: Linear regression analyses showed a 3.3 mmHg lower systolic blood pressure (SBP) and a 1.8 mmHg lower diastolic blood pressure (DBP), per 1kg higher birthweight. These associations were statistically significant after adjustment for adult weight. Birthweight was significantly and positively related to carotid arterial compliance (P = 0.050), but less so to brachial (P = 0.114) and femoral arterial compliance (P = 0.058). However, after adjustment for adult height, the strength of these associations decreased. Birthweight was not related to arterial distensibility. The association between birthweight and arterial compliance could only partly explain the association between birthweight and blood pressure. Conclusions: Lower birthweight is related to increased blood pressure, and increased arterial stiffness. However, the latter relationship can only partly explain the association between birthweight and blood pressure. Therefore, mechanisms other than arterial stiffness contribute to the birthweight—blood pressure relationship
Keyword Birthweight
blood pressure
arterial stiffness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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