Vascular Structures in Skin Tumors: A Dermoscopy Study

Argenziano, Giuseppe, Zalaudek, Iris, Corona, Rosamaria, Sera, Francesco, Cicale, Lorenza, Petrillo, Gianluca, Ruocco, Eleonora, Hofmann-Wellenhof, Rainer and Soyer, H. Peter (2004) Vascular Structures in Skin Tumors: A Dermoscopy Study. Archives of Dermatology, 140 12: 1485-1489. doi:10.1001/archderm.140.12.1485

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Author Argenziano, Giuseppe
Zalaudek, Iris
Corona, Rosamaria
Sera, Francesco
Cicale, Lorenza
Petrillo, Gianluca
Ruocco, Eleonora
Hofmann-Wellenhof, Rainer
Soyer, H. Peter
Title Vascular Structures in Skin Tumors: A Dermoscopy Study
Journal name Archives of Dermatology   Check publisher's open access policy
ISSN 0003-987X
Publication date 2004-12-01
Year available 2004
Sub-type Article (original research)
DOI 10.1001/archderm.140.12.1485
Open Access Status File (Publisher version)
Volume 140
Issue 12
Start page 1485
End page 1489
Total pages 5
Place of publication Chicago, Ill.
Publisher Journal of the American Medical Association
Language eng
Subject 110304 Dermatology
Abstract Objectives: To describe the different vascular structures seen by dermoscopy and to evaluate their association with various metanocytic and nonmelanocytic skin tumors in a large series of cases.
Formatted abstract
Objectives To describe the different vascular structures seen by dermoscopy and to evaluate their association with various melanocytic and nonmelanocytic skin tumors in a large series of cases.

Design Digital dermoscopic images of the lesions were evaluated for the presence of various morphologic types of vessels.

Setting Specialized university clinic.

Patients From a larger database, 531 excised lesions (from 517 patients) dermoscopically showing any type of vascular structures were included.

Main Outcome Measures The frequency and positive predictive value of the different vascular structures seen in various tumors were calculated, and the differences were evaluated by the {chi}2 or Fisher exact test.

Results Arborizing vessels were seen in 82.1% of basal cell carcinomas, with a 94.1% positive predictive value (P<.001). Dotted vessels were generally predictive for a melanocytic lesion (90.0%, P<.001), and were especially seen in Spitz nevi (77.8% of lesions). In melanoma, linear-irregular, dotted, and polymorphous/atypical vessels were the most frequent vascular structures, whereas milky-red globules/areas were the most predictive ones (77.8%, P = .003). The presence of erythema was most predictive for Clark nevus, whereas comma, glomerular, crown, and hairpin vessels were significantly associated with dermal/congenital nevi, Bowen disease, sebaceous hyperplasia, and seborrheic keratosis, respectively (P<.001 for all).

Conclusions Different morphologic types of vessels are associated with different melanocytic or nonmelanocytic skin tumors. Therefore, the recognition of distinctive vascular structures may be helpful for diagnostic purposes, especially when the classic pigmented dermoscopic structures are lacking.
Keyword Dermatology
Dermatology
DERMATOLOGY
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 03 Apr 2009, 20:35:18 EST by Maryanne Watson on behalf of School of Medicine