Virulence properties of asymptomatic bacteriuria Escherichia coli

Mabbett, Amanda N., Ulett, Glen C., Watts, Rebecca E., Tree, Jai J., Totsika, Makrina, Ong, Cheryl-Lynn, Wood, Jacqueline M., Monaghan, Wayne, Looke, David F., Nimmo, Graeme R., Svanborg, Catharina and Schembri, Mark A. (2009) Virulence properties of asymptomatic bacteriuria Escherichia coli. International Journal of Medical Microbiology, 299 1: 53-63. doi:10.1016/j.ijmm.2008.06.003


Author Mabbett, Amanda N.
Ulett, Glen C.
Watts, Rebecca E.
Tree, Jai J.
Totsika, Makrina
Ong, Cheryl-Lynn
Wood, Jacqueline M.
Monaghan, Wayne
Looke, David F.
Nimmo, Graeme R.
Svanborg, Catharina
Schembri, Mark A.
Title Virulence properties of asymptomatic bacteriuria Escherichia coli
Formatted title
Virulence properties of asymptomatic bacteriuria Escherichia coli
Journal name International Journal of Medical Microbiology   Check publisher's open access policy
ISSN 1438-4221
1618-0607
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ijmm.2008.06.003
Volume 299
Issue 1
Start page 53
End page 63
Total pages 11
Place of publication Jena, Germany
Publisher Urban und Fischer Verlag
Language eng
Subject C1
0605 Microbiology
Formatted abstract
In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E. coli evade immune detection after the establishment of bacteriuria.
© 2008 Elsevier GmbH.All rights reserved.
Keyword Asymptomatic bacteriuria
Escherichia coli
Fimbriae
Urinary tract infection
Proinflammatory cytokines
Host response
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Fri, 03 Apr 2009, 20:20:38 EST by Jennifer Falknau on behalf of Faculty of Science