New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris

Yong, Ken W. L., Salim, Angela A. and Garson, Mary J. (2008) New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris. Tetrahedron, 2008 64: 6733-6738. doi:10.1016/j.tet.2008.05.008


Author Yong, Ken W. L.
Salim, Angela A.
Garson, Mary J.
Title New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris
Formatted title
New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
Publication date 2008-07-07
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.tet.2008.05.008
Open Access Status Not yet assessed
Volume 2008
Issue 64
Start page 6733
End page 6738
Total pages 6
Place of publication Kidlington, Oxford, UK
Publisher Pergamon
Language eng
Subject C1
030502 Natural Products Chemistry
970103 Expanding Knowledge in the Chemical Sciences
Abstract Chemical analysis of a chromodorid nudibranch has provided two new diterpene metabolites 1 and 2 together with the known metabolites 3–6. In an NMR study, the dialdehyde metabolite 1 underwent facile conversion to cyclic hemiacetals 8–9 on exposure to methanol, a reaction that mimics chemical conversions that may occur during the isolation of some diterpenes from molluscs and sponges. Compounds 1, 2, 5 and 8 showed moderate cytotoxicity against P388 cells (IC50=1.2–4.1 μg/mL).
Keyword Diterpene
Spongian
Isocopalane
Acetal formation
NMR
Molluscs, Chromodoris
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 03 Apr 2009, 20:02:20 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences