Prediction of urinary albumin to creatinine ratio (ACR) by multiple potential risk factors in an Australian Aboriginal cohort

Wang, Zaiman, Hoy, Wendy E. and Wang, Zhiqiang (2008). Prediction of urinary albumin to creatinine ratio (ACR) by multiple potential risk factors in an Australian Aboriginal cohort. In: Australasian Epidemiologist. Population Health Congress 2008: A Global World - Practical Action for Health and Well Being, Brisbane, Australia, (29-31). 6-9 July, 2008.


Author Wang, Zaiman
Hoy, Wendy E.
Wang, Zhiqiang
Title of paper Prediction of urinary albumin to creatinine ratio (ACR) by multiple potential risk factors in an Australian Aboriginal cohort
Conference name Population Health Congress 2008: A Global World - Practical Action for Health and Well Being
Conference location Brisbane, Australia
Conference dates 6-9 July, 2008
Proceedings title Australasian Epidemiologist   Check publisher's open access policy
Place of Publication Canberra, Australia
Publisher Australasian Epidemiological Association
Publication Year 2008
Sub-type Fully published paper
ISSN 1327-8835
Volume 15
Issue 2
Start page 29
End page 31
Total pages 3
Collection year 2009
Language eng
Formatted Abstract/Summary
Objective:
Albuminuria marks renal disease and cardiovascular risk. Our objective was to explore the association of urine albumin to creatinine ratio (ACR) values with multiple potential risk factors in one high risk population and to calculate the population attributable risk (PAR) of albuminuria associated with these predictors.

Research design and methods:
ACR was measured using immunoassay in the urine of a total of 618 Aboriginal people aged 18-76 years who were screened between 1992 and 1997. Simple anthropometric indices, blood pressure, glucose, lipoprotein profiles, C-reactive protein (CRP), uric acid, serum creatinine, album and cystatin C were also measured. Logistic regression models were used to explore the association between ACR and potential predictors.

Results:
Average ACR values were 3.5 mg/mmol (3.0- 4.2) (geometric mean, 95% CI). Hypertension, diabetes, dyslipidaemia, low serum albumin, high CRP and high uric acid were identified as independent predictors for albuminuria. The contributions of diabetes, hypertension and dyslipidaemia to albuminuria were 32%, 24% and 21%, respectively.

Conclusions:

Hypertension, diabetes, dyslipidaemia, CRP, uric acid and low serum albumin were independent predictors of ACR in this setting. These relationships emphasise the important associations of the metabolic syndrome and inflammation with cardiovascular risk and with renal disease. The potential associations of additional factors like low birth weight, infections and genetic factors also need to be explored.
Subjects C1
9203 Indigenous Health
111701 Aboriginal and Torres Strait Islander Health
111706 Epidemiology
1103 Clinical Sciences
1117 Public Health and Health Services
Keyword Urinary albumin
Creatinine ratio
Australian Aboriginal cohort
Albuminuria
Epidemiology
Creatinine
Urine
Oceanic ancestry group
Adolescent
Adult
Diabetes mellitus
Aborigines
Dyslipidemias
Serum albumin
Uric acid
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Conference Precis published in Australasian Epidemiologist. Meets requirements for inclusion in 2009 HERDC as C1 Published under "Population Health Congress 2008: An AEA Précis"

 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Fri, 03 Apr 2009, 10:24:04 EST by Amy Wong on behalf of Medicine - Royal Brisbane and Women's Hospital