Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

McGrath, John J., Saha, Sukanta, Chant, David C. and Welham, Joy (2008) Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality. Epidemiologic Reviews, 30 1: 67-76. doi:10.1093/epirev/mxn001

Author McGrath, John J.
Saha, Sukanta
Chant, David C.
Welham, Joy
Title Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality
Journal name Epidemiologic Reviews   Check publisher's open access policy
ISSN 0193-936X
Publication date 2008-11-01
Year available 2008
Sub-type Article (original research)
DOI 10.1093/epirev/mxn001
Volume 30
Issue 1
Start page 67
End page 76
Total pages 10
Place of publication Cary, NC, USA
Publisher Oxford Universtiy Press
Collection year 2009
Language eng
Subject C1
321204 Mental Health
730211 Mental health
Formatted abstract
Recent systematic reviews have encouraged the psychiatric research community to reevaluate the contours of schizophrenia epidemiology.

This paper provides a concise overview of three related systematic reviews on the incidence, prevalence, and mortality associated with schizophrenia. The reviews shared key methodological features regarding search strategies, analysis of the distribution of the frequency estimates, and exploration of the influence of key variables ( sex, migrant status, urbanicity, secular trend, economic status, and latitude). Contrary to previous interpretations, the incidence of schizophrenia shows prominent variation between sites. The median incidence of schizophrenia was 15.2/100,000 persons, and the central 80% of estimates varied over a fivefold range (7.7-43.0/100,000). The rate ratio for males: females was 1.4:1. Prevalence estimates also show prominent variation. The median lifetime morbid risk for schizophrenia was 7.2/1,000 persons.

On the basis of the standardized mortality ratio, people with schizophrenia have a two-to threefold increased risk of dying ( median standardized mortality ratio 5 2.6 for all-cause mortality), and this differential gap in mortality has increased over recent decades. Compared with native-born individuals, migrants have an increased incidence and prevalence of schizophrenia. Exposures related to urbanicity, economic status, and latitude are also associated with various frequency measures. In conclusion, the epidemiology of schizophrenia is characterized by prominent variability and gradients that can help guide future research.
Keyword incidence
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Please Note: Alternative title is The Epidemiology of Schizophrenia: A concise overview of incidence, prevalence, and mortality

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 461 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 03 Apr 2009, 01:57:14 EST by Debra McMurtrie on behalf of Queensland Brain Institute