The international endogene study: a collection of families for genetic research in endometriosis

Treloar, Susan, Hadfield, Ruth, Montgomery, Grant, Lambert, ,Ann, Wicks, Jacki, Barlow, David H., O’Connor, Daniel T., Kennedy, Stephen and International Endogene Study Group (2002) The international endogene study: a collection of families for genetic research in endometriosis. Fertility and Sterility, 78 4: 679-685. doi:10.1016/S0015-0282(02)03341-1


Author Treloar, Susan
Hadfield, Ruth
Montgomery, Grant
Lambert, ,Ann
Wicks, Jacki
Barlow, David H.
O’Connor, Daniel T.
Kennedy, Stephen
International Endogene Study Group
Title The international endogene study: a collection of families for genetic research in endometriosis
Journal name Fertility and Sterility   Check publisher's open access policy
ISSN 0015-0282
1556-5653
Publication date 2002-10-01
Sub-type Article (original research)
DOI 10.1016/S0015-0282(02)03341-1
Open Access Status Not yet assessed
Volume 78
Issue 4
Start page 679
End page 685
Total pages 7
Place of publication New York
Publisher Elsevier
Language eng
Subject 111799 Public Health and Health Services not elsewhere classified
Formatted abstract
Objective: The aim of the International Endogene Study is to discover genes that influence susceptibility to endometriosis.

Design: The study brings together two research groups based in Australia and the United Kingdom that independently have been collecting families for linkage analysis and candidate gene studies. Both groups used similar methods to recruit families, obtain clinical notes, assign disease status based on the operative records and available histology, and collect common clinical data including age at onset of symptoms, age at diagnosis, and symptoms experienced.

Setting: Recruitment has been mainly from Australia, the United Kingdom, and the United States.

Patient(s): All affected participants have surgically confirmed disease.

Intervention(s)
: None.

Main Outcome Measure(s): Clinical and epidemiological data.

Result(s)
: To date, >1,100 families with affected sisters have been recruited, and >1,200 triads (affected women and both parents), for case-control studies.

Conclusion(s)
: We have created the largest resource yet assembled of clinical data and DNA for linkage and association studies in endometriosis. The increase in power to detect susceptibility genes vindicates the decision to merge the two studies and demonstrates the value of large-scale international collaboration.
Keyword Endometriosis
genetic
epidemiology
linkage studies
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Fri, 03 Apr 2009, 01:03:30 EST by Ms Karen Naughton on behalf of School of Public Health