Applications of molecular testing in clinical laboratories for the diagnosis and control of gonorrhea

Tapsall, John, David Whiley and Sloots, Theodorus P. (2006) Applications of molecular testing in clinical laboratories for the diagnosis and control of gonorrhea. Future Microbiology, 1 3: 317-324. doi:10.2217/17460913.1.3.317


Author Tapsall, John
David Whiley
Sloots, Theodorus P.
Title Applications of molecular testing in clinical laboratories for the diagnosis and control of gonorrhea
Journal name Future Microbiology   Check publisher's open access policy
ISSN 1746-0913
Publication date 2006-10-01
Year available 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/17460913.1.3.317
Open Access Status
Volume 1
Issue 3
Start page 317
End page 324
Total pages 8
Editor Andrew, P. W.
Anne, J.
Armstrong, G.
Blomfield, I.
Bonomo, R. A.
Calderone, R. A.
Et Al
Place of publication United Kingdom
Publisher Future Medicine Ltd.
Language eng
Subject C1
060502 Infectious Agents
060503 Microbial Genetics
060506 Virology
920109 Infectious Diseases
Abstract The potential for enhanced diagnosis and cotrol of gonococcal infection through the application of advances in molecular medicine is ow being realized. However, the introduction of diagnostic nucleic acid amplification assays (NAATs) revealed some significant limitations of these applications. Resolution of some, but not all, of these problems has led to recommendations for refined testing algorithms and a better recognition and acceptance of the limitations of NAATs. Resource restriction has limited the use of diagnostic NAATs, especially in less-developed countries where disease rates are highest. However, NAATs, especially in less-developed countries where disease rates are highest. However, NAATs have also proved useful in public health approaches to fonorrhea control in all settings. Additional applications including molecular typing of gonococcal to identify and interupt gonococcal transmission chains and definition of antimicrobial resistance patterns in the gonococcus have been proposed. These approaches, especially those for antimicrobial resistance determination, have been less successful for a number of reasons, including their cost and other unresolved issues.
Keyword Enhanced diagnosis
control of gonococcal infection
molecular medicine
NAAT
nucleic acid amplification assays
molecular typing
gonococcus
antimicrobial resistance
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Clinical Medical Virology Centre Publications
 
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Created: Thu, 02 Apr 2009, 21:16:38 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre