Radiological and pathological findings of interval cancers in a multi-centre, randomized, controlled trial of mammographic screening in women from age 40–41 years

Evans, A. J., Kutt, E., Record, C., Waller, M., Bobrow, L. and Moss, S. (2007) Radiological and pathological findings of interval cancers in a multi-centre, randomized, controlled trial of mammographic screening in women from age 40–41 years. Clinical Radiology, 62 4: 348-352. doi:10.1016/j.crad.2006.10.010


Author Evans, A. J.
Kutt, E.
Record, C.
Waller, M.
Bobrow, L.
Moss, S.
Title Radiological and pathological findings of interval cancers in a multi-centre, randomized, controlled trial of mammographic screening in women from age 40–41 years
Journal name Clinical Radiology   Check publisher's open access policy
ISSN 0009-9260
Publication date 2007-04-01
Sub-type Article (original research)
DOI 10.1016/j.crad.2006.10.010
Open Access Status
Volume 62
Issue 4
Start page 348
End page 352
Total pages 5
Place of publication London
Publisher W.B. Saunders.
Language eng
Subject 010402 Biostatistics
111706 Epidemiology
Formatted abstract
Aim
The aim of this study was to analyse the radiographic findings of the screening mammograms of women with interval cancer who participated in a multi-centre, randomized, controlled trial of mammographic screening in women from age 40–48 years.

Materials and methods


The screening and diagnostic mammograms of 208 women with interval cancers were reviewed. Abnormalities were classified as malignant, subtle and non-specific.

Results


Eighty-seven (42%) of women had true, 66 (32%) occult and 55 (26%) false-negative interval cancers. The features most frequently missed or misinterpreted were granular microcalcification (38%), asymmetric density (27%) and distortion (22%). Thirty-seven percent of abnormal previous screens were classified as malignant, 39% subtle change and 21% as non-specific. Granular calcifications were significantly more common on the diagnostic mammograms of false-negative interval cancers than those of true interval cancers (28 versus 14%, p = 0.04). Occult interval cancers were more likely to be <10 mm and <15 mm in invasive pathological size than other interval cancers (p = 0.03 and 0.005, respectively). True interval cancers were more likely to be histologically grade 3 than other interval cancers (p = 0.04). Women who developed true and false-negative interval cancers had similar background patterns, but women with occult cancers had a higher proportion of dense patterns (p < 0.05).

Conclusion


Interval cancers in a young screening population have a high proportion of occult lesions that are small and occur in dense background patterns. The proportion of interval cancers that are false negative is similar that seen in older populations and granular microcalcification is the commonest missed mammographic feature.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Military and Veterans' Health Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 02 Apr 2009, 01:03:18 EST by Paul Rollo on behalf of Library Corporate Services