Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer

Davidson, Wendy, Ash, Susan, Capra, Sandra and Bauer, Judith (2004) Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer. Clinical Nutrition, 23 2: 239-247. doi:10.1016/j.clnu.2003.07.001


Author Davidson, Wendy
Ash, Susan
Capra, Sandra
Bauer, Judith
Title Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer
Journal name Clinical Nutrition   Check publisher's open access policy
ISSN 0261-5614
Publication date 2004-04-01
Year available 2004
Sub-type Article (original research)
DOI 10.1016/j.clnu.2003.07.001
Open Access Status
Volume 23
Issue 2
Start page 239
End page 247
Total pages 9
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 111101 Clinical and Sports Nutrition
11 Medical and Health Sciences
1111 Nutrition and Dietetics
1112 Oncology and Carcinogenesis
Abstract Background Et aims: Cancer-induced weight toss is associated with poor outcomes and is common in pancreatic cancer. The aims were to determine whether stabilising weight loss for patients with unresectable pancreatic cancer was associated with improved survival and quality of life (QoL) and to identify determinants of weight stabilisation.
Formatted abstract
Background & aims:
Cancer-induced weight loss is associated with poor outcomes and is common in pancreatic cancer. The aims were to determine whether stabilising weight loss for patients with unresectable pancreatic cancer was associated with improved survival and quality of life (QoL) and to identify determinants of weight stabilisation.

Methods:

A post hoc analysis was performed using data from 107 patients in a multicentre trial. Patients were categorised as weight losing (>1 kg lost) or weight stable (less-than-or-equals, slant1 kg lost) after an 8 week nutrition intervention period. Group survival duration (Kaplan Meier) and QoL (EORTC QLQ-C30) were compared. Predictors of weight stability were determined using logistic regression analysis.

Results:
Patients with weight stabilisation survived longer from baseline (log rank test 5.53, P=0.019). They also reported higher QoL scores (P=0.037) and a greater mean energy intake (P<0.001) at Week 8 than those who continued to lose weight. The absence of nausea and vomiting (OR 6.5, P=0.010) and female gender (OR 5.2, P=0.020) were independent determinants of weight stabilisation.

Conclusions:
Weight stabilisation over an 8 week period in weight-losing patients with unresectable pancreatic cancer was associated with improved survival duration and QoL.
Keyword Diet therapy
Nutrition disorders
Nutrition
Pancreatic neoplasms
Cachexia
Weight loss
Quality of life;
Survival
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
 
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Created: Thu, 02 Apr 2009, 00:56:18 EST by Ms Karen Naughton on behalf of Faculty Of Health Sciences