Effect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet

Sabboh, Houda, Horcajada, Marie-Noëlle, Coxam, Véronique, Tressol, Jean-Claude, Besson, Catherine, Rémésy, Christian and Demigné, Christian (2005) Effect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet. The British Journal of Nutrition, 94 2: 192-197. doi:10.1079/BJN20051474

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Author Sabboh, Houda
Horcajada, Marie-Noëlle
Coxam, Véronique
Tressol, Jean-Claude
Besson, Catherine
Rémésy, Christian
Demigné, Christian
Title Effect of potassium salts in rats adapted to an acidogenic high-sulfur amino acid diet
Journal name The British Journal of Nutrition   Check publisher's open access policy
ISSN 1475-2662
Publication date 2005-08-01
Sub-type Article (original research)
DOI 10.1079/BJN20051474
Open Access Status File (Publisher version)
Volume 94
Issue 2
Start page 192
End page 197
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Subject 111199 Nutrition and Dietetics not elsewhere classified
Abstract Low-grade metabolic acidosis, consecutive to excessive catabolism of sulfur amino acids and a high dietary Na:K ratio, is a common feature of Western food habits. This metabolic alteration may exert various adverse physiological effects, especially on bone, muscle and kidneys. To assess the actual effects of various K salts, a model of the Westernised diet has been developed in rats: slight protein excess (20 % casein); cations provided as non-alkalinising salts; high Na:K ratio. This diet resulted in acidic urine (pH 5·5) together with a high rate of divalent cation excretion in urine, especially Mg. Compared with controls, K supplementation as KCl accentuated Ca excretion, whereas potassium bicarbonate or malate reduced Mg and Ca excretion and alkalinised urine pH (up to 8). In parallel, citraturia was strongly increased, together with 2-ketoglutarate excretion, by potassium bicarbonate or malate in the diet. Basal sulfate excretion, in the range of 1 mmol/d, was slightly enhanced in rats fed the potassium malate diet. The present model of low-grade metabolic acidosis indicates that potassium malate may be as effective as KHCO3 to counteract urine acidification, to limit divalent cation excretion and to ensure high citrate concentration in urine.
Keyword Low-grade acidosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Nutrition and Food Sciences Publications
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Created: Thu, 02 Apr 2009, 00:55:37 EST by Ms Lynette Adams on behalf of Centre for Nutrition and Food Sciences