Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer

Bauer, Judith, Capra, Sandra, Battistutta, Diana, Davidson, Wendy and Ash, Susan (2005) Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer. Clinical Nutrition, 24 6: 998-1004. doi:10.1016/j.clnu.2005.07.002


Author Bauer, Judith
Capra, Sandra
Battistutta, Diana
Davidson, Wendy
Ash, Susan
Title Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer
Journal name Clinical Nutrition   Check publisher's open access policy
ISSN 0261-5614
Publication date 2005-12-01
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.clnu.2005.07.002
Open Access Status DOI
Volume 24
Issue 6
Start page 998
End page 1004
Total pages 7
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 111102 Dietetics and Nutrigenomics
11 Medical and Health Sciences
1104 Complementary and Alternative Medicine
1111 Nutrition and Dietetics
1112 Oncology and Carcinogenesis
Abstract Background Et Aims: There are few well-designed studies evaluating the effect of oral nutrition supplements in patients with cancer cachexia. The aim of this study, in a posthoc analysis, was to examine the effect of dietary compliance on intake and body composition in patients with unresectable pancreatic cancer.
Formatted abstract
Background & Aims
There are few well-designed studies evaluating the effect of oral nutrition supplements in patients with cancer cachexia. The aim of this study, in a posthoc analysis, was to examine the effect of dietary compliance on intake and body composition in patients with unresectable pancreatic cancer.

Methods

Two hundred patients were randomised to receive 2 cans/day of a protein and energy dense, oral nutrition supplement ±n-3 fatty acids in an international, multi-centre randomised trial over 8 weeks. Dietary compliance was defined a priori as consumption of a minimum of 1.5 cans/day of either supplement. Body composition, dietary intake and quality of life were measured at baseline, 4 and 8 weeks.

Results

On average, there were significant differences in energy intake (501 kcal), protein intake (25.4 g) and weight (1.7 kg) between patients who were compliant with the nutrition prescription compared to noncompliant patients controlling for n-3 fatty acid randomisation, baseline weight and quality of life. Over the 8-week period, there was significant improvement in weight only. There was no significant difference in the energy intake from meals of the total group over the 8 weeks.

Conclusions
Compliance with the prescription of 1.5 cans of a protein and energy dense, oral nutrition supplement ±n-3 fatty acids improved nutrition related outcomes in untreated pancreatic cancer patients. This level of supplement intake does not inhibit meal intake.
Keyword Diet therapy
Nutrition disorders
Nutrition
Nutrition prescription
Nutrition intervention
Pancreatic cancer
Quality of life
Cancer
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
 
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Created: Thu, 02 Apr 2009, 00:44:12 EST by Ms Karen Naughton on behalf of Faculty Of Health Sciences