Identification of loci associated with schizophrenia by genome-wide association and follow-up

Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, Nikolov, Ivan, Hamshere, Marian, Carroll, Liam, Georgieva, Lyudmila, Dwyer, Sarah, Holmans, Peter, Marchini, Johnthan L., Spencer, Chris C. A., Howie, Bryan, Leung, Hin-Tak, Hartmann, Annette M., Moller, Hans-Jurgen, Morris, Derek W., Shi, YongYong, Feng, GuoYin, Hoffmann, Per, Propping, Peter, Vasilescu, Catalina, Maier, Wolfgang, Rietschel, Marcella, Zammit, Stanley, Schumacher, Johannes, Quinn, Emma M., Schulze, Thomas G., Williams, Nigel M., Giegling, Ina, Iwata, Nakao, Ikeda, Masashi, Darvasi, Ariel, Shifman, Sagiv, He, Lin, Duan, Jubao, Sanders, Alan R., Levinson, Douglas F., Gejman, Pablo V., Molecular Genetics of Schizophrenia, Cichon, Sven, No¨then, Markus M., Gill, Michael, Corvin, Aiden, Rujescu, Dan, Kirov, George, Owen, Michael J. and Mowry, Bryan (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40 9: 1053-1055. doi:10.1038/ng.201

Author Donovan, Michael C.
Craddock, Nicholas
Norton, Nadine
Williams, Hywel
Peirce, Timothy
Moskvina, Valentina
Nikolov, Ivan
Hamshere, Marian
Carroll, Liam
Georgieva, Lyudmila
Dwyer, Sarah
Holmans, Peter
Marchini, Johnthan L.
Spencer, Chris C. A.
Howie, Bryan
Leung, Hin-Tak
Hartmann, Annette M.
Moller, Hans-Jurgen
Morris, Derek W.
Shi, YongYong
Feng, GuoYin
Hoffmann, Per
Propping, Peter
Vasilescu, Catalina
Maier, Wolfgang
Rietschel, Marcella
Zammit, Stanley
Schumacher, Johannes
Quinn, Emma M.
Schulze, Thomas G.
Williams, Nigel M.
Giegling, Ina
Iwata, Nakao
Ikeda, Masashi
Darvasi, Ariel
Shifman, Sagiv
He, Lin
Duan, Jubao
Sanders, Alan R.
Levinson, Douglas F.
Gejman, Pablo V.
Molecular Genetics of Schizophrenia
Cichon, Sven
No¨then, Markus M.
Gill, Michael
Corvin, Aiden
Rujescu, Dan
Kirov, George
Owen, Michael J.
Mowry, Bryan
Title Identification of loci associated with schizophrenia by genome-wide association and follow-up
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2008-09-01
Sub-type Article (original research)
DOI 10.1038/ng.201
Open Access Status Not Open Access
Volume 40
Issue 9
Start page 1053
End page 1055
Total pages 3
Editor Myles Axton
Place of publication New York, U.S.A.
Publisher Nature Publishing Group
Language eng
Subject 321204 Mental Health
920209 Mental Health Services
111714 Mental Health
Formatted abstract
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10-9).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 01 Apr 2009, 21:33:15 EST by Carmel Meir on behalf of School of Medicine