Nerve growth factor/nuclear factor-κB pathway as a therapeutic target in breast cancer

Naderi, Ali and Hughes-Davies, Luke (2009) Nerve growth factor/nuclear factor-κB pathway as a therapeutic target in breast cancer. Journal of Cancer Research and Clinical Oncology, 135 2: 211-216. doi:10.1007/s00432-008-0455-6


Author Naderi, Ali
Hughes-Davies, Luke
Title Nerve growth factor/nuclear factor-κB pathway as a therapeutic target in breast cancer
Journal name Journal of Cancer Research and Clinical Oncology   Check publisher's open access policy
ISSN 0171-5216
1432-1335
Publication date 2009-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00432-008-0455-6
Open Access Status Not Open Access
Volume 135
Issue 2
Start page 211
End page 216
Total pages 6
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Subject C1
920102 Cancer and Related Disorders
111201 Cancer Cell Biology
Formatted abstract
Introduction: Nuclear factor-κB pathway (NF-κB) is activated in many breast cancers. NF-k{cyrillic}B has interactions with other pathways such as the nerve growth factor (NGF) pathway, which is involved in the survival and proliferation of breast cancer cells. NGF treatment of breast cancer cells activates NF-κB resulting in the inhibition of ceramide-induced apoptosis. NGF effects on apoptosis and cell proliferation are mediated through p75NTR and p140TrkA receptors, respectively. In this study we investigate the NGF/NF-κB pathway as a therapeutic target in breast cancer.

Results
: We demonstrate that p75NTR inhibitor Pep5, p140TrkA inhibitor K-252a, and NF-κB inhibitor BAY11-7085 have pro-apoptotic and anti-proliferation activities in breast cancer cells. We also show a synergy in combining the NGF receptor inhibitors with the conventional breast cancer treatments tamoxifen and taxol.

Conclusion
: These data suggest that NGF/NF-κB pathway is a potential therapeutic target in breast cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 21 August 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
UQ Diamantina Institute Publications
 
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Created: Wed, 01 Apr 2009, 21:25:31 EST by Kylie Hengst on behalf of UQ Diamantina Institute