Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro

Cross, S. E., Russel, M., Southwell, I. and Roberts, M. S. (2008) Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro. European Journal of Pharmaceutics And Biopharmaceutics, 69 1: 214-222. doi:10.1016/j.ejpb.2007.10.002


Author Cross, S. E.
Russel, M.
Southwell, I.
Roberts, M. S.
Title Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro
Journal name European Journal of Pharmaceutics And Biopharmaceutics   Check publisher's open access policy
ISSN 0939-6411
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ejpb.2007.10.002
Open Access Status Not yet assessed
Volume 69
Issue 1
Start page 214
End page 222
Total pages 9
Editor Gurny, R.
Place of publication Netherlands
Publisher Elsevier B V
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111502 Clinical Pharmacology and Therapeutics
Abstract The safety of topical application of Australian tea tree Oil (TTO) is confounded by a lack of transdermal penetration data, which adequately informs opinions and recommendations. In this study we applied TTO in its pure form and as a 20% solution in ethanol in vitro to human epidermal membranes from three different donors, mounted in horizontal Franz-type diffusion cells, using normal 'in use' dosing conditions (10 mg/cm(2)). In addition, we examined the effect of partially occluding the application site on the penetration of TTO components. Our data showed that only a small quantity of TTO components, 1.1-1.9% and 2-4% of the applied amount following application of a 20% TTO solution and pure TTO, respectively, penetrated into or through human epidermis. The largest TTO component penetrating the skin was terpinen-4-ol. Following partial occlusion of the application site, the penetration of terpinen-4-ol increased to approximately 7% of the applied TTO. Measurement of the rate of evaporation of tea tree oil from filter paper (7.4 mg/cm(2)) showed that 98% of the oil evaporated in 4 hours. Overall, it is apparent that the penetration of TTO components through human skin is limited. (C) 2007 Elsevier B.V. All rights reserved.
Keyword Pharmacology & Pharmacy
Pharmacology & Pharmacy
PHARMACOLOGY & PHARMACY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 01 Apr 2009, 07:13:13 EST by Maree Knight on behalf of School of Medicine